{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:26:40Z","timestamp":1786692400711,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A method developed and validated for the assay of fenofibrate in tablet dosage form by isocratic RP\u2010UHPLC\u2013UV technique has been rapid and precise. The material was chromatographed on Shim\u2010pack Velox C18 column (50\u2009\u00d7\u20092.1\u2009mm, 1.8\u2009\u03bcm) at 40\u00b0C with isocratic mobile phase: acidified water\/acetonitrile (60:40, v\/v) at 0.4\u2009mL\/min and at a detection wavelength of 286\u2009nm. The total run time was 6.0\u2009min and fenofibrate eluted at ~2.4\u2009min. The method was linear over 10\u201390\u2009\u03bcg\/mL (r\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.9995) with LOD\/LOQ of 0.239\/0.673\u2009\u03bcg\/mL. The precision and accuracy (RSD less than 2% and 96%\u2013100% recovery) comply with ICH Q2(R1) requirements both intra\u2010day and inter\u2010day. The present UHPLC method significantly shortens the analysis time and solvent consumption compared with the reported HPLC methods (typical run time &gt;\u20098\u201320\u2009min) without compromising of the sensitivity, which allows to use the present method for routine quality control of fenofibrate tablets.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70577","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:49:15Z","timestamp":1785250155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of Isocratic RP\u2010UHPLC Method for Assay of Fenofibrate Tablet"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1206-1552","authenticated-orcid":false,"given":"Jyoti","family":"Yadav","sequence":"first","affiliation":[{"name":"Sanskaram College of Pharmacy Sanskaram University  Jhajjar Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9529-5448","authenticated-orcid":false,"given":"Saurav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Gurugram University  Gurugram Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabodh. 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