{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:26:43Z","timestamp":1786692403540,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A stability\u2010indicating reverse\u2010phase high\u2010performance liquid chromatographic (RP\u2010HPLC) method was developed and validated for quantitative estimation of satranidazole in bulk drug and tablet dosage form, followed by LC\u2013MS characterization of stress\u2010induced degradation products. Chromatographic separation was achieved on a HiQ Sil C18 column (250\u2009\u00d7\u20094.6\u2009mm, 5\u2009\u03bcm) using methanol:0.1% formic acid in water (60:40, v\/v) as mobile phase at a flow rate of 1.0\u2009mL\/min with UV detection at 317\u2009nm. The method exhibited satisfactory linearity over 5\u201330\u2009\u03bcg\/mL with a correlation coefficient of 0.999. Stress\u2010induced degradation studies performed under acidic, alkaline, oxidative, thermal, and photolytic conditions demonstrated significant degradation under alkaline and photolytic stress. The developed method successfully resolved satranidazole from its degradation products. LC\u2013MS analysis enabled tentative characterization of major degradants and facilitated the proposal of probable degradation pathways. The developed method is suitable for routine stability assessment and pharmaceutical quality control of satranidazole formulations.<\/jats:p>","DOI":"10.1002\/bmc.70582","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:20:38Z","timestamp":1785903638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stress\u2010Induced Degradation Profiling of Satranidazole Using Stability\u2010Indicating RP\u2010HPLC Method and LC\u2013MS Characterization"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2181-2395","authenticated-orcid":false,"given":"Bhairavi","family":"Saraf","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Basic and Applied Sciences Sangam University  Bhilwara Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-6595","authenticated-orcid":false,"given":"Preeti","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Basic and Applied Sciences Sangam University  Bhilwara Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8871-575X","authenticated-orcid":false,"given":"Rahul","family":"Somani","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance Alkem Laboratories Ltd  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7897\/2230-8407.04442"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"170","article-title":"Validated HPTLC Method for Simultaneous Estimation of Ofloxacin and Satranidazole in Tablet Dosage Form","volume":"4","author":"Balammal G.","year":"2014","journal-title":"International Journal of Innovative Drug Discovery"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"57","article-title":"UV Spectrophotometric Estimation of Satranidazole in Periodontal Gels","volume":"4","author":"Bansal K.","year":"2013","journal-title":"International Journal of Pharmaceutical Quality Assurance"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"681","article-title":"Reverse Phase High Performance Liquid Chromatographic Method for Determination of Satranidazole in Pharmaceutical Formulations","volume":"4","author":"Basavasewara Rao M. 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