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This study evaluated the anticoccidial efficacy of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Coriandrum sativum<\/jats:italic>\n                    <\/jats:styled-content>\n                    methanolic extract (CME) against\n                    <jats:italic>Eimeria papillata<\/jats:italic>\n                    infection in mice. Phytochemical profiling of CME was conducted using liquid chromatography\u2013mass spectrometry (LC\u2013MS), and identified compounds were subjected to in silico molecular docking. Twenty\u2010five male Swiss albino mice were divided into the following five groups as follows: Group 1: noninfected, nontreated (control), Group 2: CME administered control, Group 3: infected with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. papillata<\/jats:italic>\n                    <\/jats:styled-content>\n                    , Group 4: infected+CME treated group (300\u2009mg\/kg), and Group 5: infected+amprolium treated group (120\u2009mg\/kg). Mice were orally infected with 1\u2009\u00d7\u200910\n                    <jats:sup>3<\/jats:sup>\n                    sporulated oocysts and treated for 5 days. Docking analysis revealed strong binding affinities of several chromatographic CME constituents toward elongation factor Tu (tufA), with docking scores exceeded amprolium's binding affinity. In\u00a0vivo, CME significantly restored goblet cell counts and upregulated MUC\u20102 expression. It reduced pathogenic\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salmonella typhi<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    colonization, downregulated inducible nitric oxide synthase and CD4 expression, enhanced catalase activity, as well as suppressed pro\u2010inflammatory cytokines interleukin\u20101beta (IL\u20101\u03b2) and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1). These findings demonstrate that CME exerts anticoccidial, antioxidant, anti\u2010inflammatory, and culture\u2010based bacterial effects, highlighting its potential as a natural therapeutic agent against murine coccidiosis.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70596","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:25:24Z","timestamp":1786760724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Evaluation of\n                    <scp>\n                      <i>Coriandrum sativum<\/i>\n                    <\/scp>\n                    Extract Against Murine\n                    <i>Eimeria papillata<\/i>\n                    Infection and In Silico Analysis of Its Identified Phytochemicals"],"prefix":"10.1002","volume":"40","author":[{"given":"Abdulsalam","family":"Alkhudhayri","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science University of Hafr Al Batin  Hafr Al Batin Saudia Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-0014","authenticated-orcid":false,"given":"Shaimaa M.","family":"Kasem","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-5800","authenticated-orcid":false,"given":"Mohamed A.","family":"Dkhil","sequence":"additional","affiliation":[{"name":"Zoology and Entomology Department, Faculty of Science Capital University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Ismaeil","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-1980","authenticated-orcid":false,"given":"Saeed","family":"El\u2010Ashram","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9487-2113","authenticated-orcid":false,"given":"Kareem A.","family":"Abdelmeguid","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine University of Latvia  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-2463","authenticated-orcid":false,"given":"Felwa A.","family":"Thagfan","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Princess Nourah bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2107-0691","authenticated-orcid":false,"given":"Nabila M.","family":"Mira","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Kafrelsheikh University  Kafr Elsheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"61","article-title":"Comparative Efficacy of Selected Anticoccidial Drugs in Ambarorow Sheep Naturally Infected With Enteric Coccidia in South Darfur, Sudan","volume":"20","author":"Abakar A. 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