{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:07:30Z","timestamp":1789661250571,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Based on serum pharmacochemistry and network pharmacology, the pharmacodynamic material basis and mechanism of Xiangju tablets (XJPs) in the treatment of rhinitis and sinusitis were discussed. UPLC\u2010QTOF\u2010MS\/MS technology combined with Compound Discover 3.0 was used to analyze and identify the in\u00a0vivo and in\u00a0vitro components of XJP. The blood components of XJP were obtained. The protein interaction network was constructed by network pharmacology, combined with GO functional analysis and KEGG enrichment analysis to reveal the key active components and potential mechanism of XJP in the treatment of rhinitis and sinusitis. A total of 423 compounds were identified in XJP, of which 41 were blood components, including gallic acid, chlorogenic acid, caffeic acid, epicatechin, rutin, rosmarinic acid, and linarin. These active components may regulate PI3K\u2010Akt, MAPK, Ras, Rap1, and other signaling pathways through key targets such as GAPDH, MAPK3, SRC, AKT1, CASP3, and IL6. XJP exerts the effect of treating rhinitis and sinusitis through multicomponent\u2013multitarget\u2013multipathway. This study provides a reference for the study of the mechanism of XJP in the treatment of rhinitis and sinusitis and provides new ideas for the development of new dosage forms for targeted treatment of rhinitis and sinusitis.<\/jats:p>","DOI":"10.1002\/bmc.70615","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:56:31Z","timestamp":1789433791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Blood Components of Xiangju Tablets Based on UPLC\u2010QTOF\u2010MS\/MS and Network Pharmacology"],"prefix":"10.1002","volume":"40","author":[{"given":"Xuan","family":"Wei","sequence":"first","affiliation":[{"name":"School of Pharmacy Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Duan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital Shaanxi University of Chinese Medicine  Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2172-756X","authenticated-orcid":false,"given":"Xiao","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shaanxi University of Chinese Medicine  Xianyang China"},{"name":"Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X23500374"},{"issue":"02","key":"e_1_2_11_3_1","first-page":"23","article-title":"Efficacy of Fragrant Chrysanthemum Tablets in the Treatment of Chronic Sinusitis in Children","volume":"37","author":"Chen J.","year":"2022","journal-title":"Chinese Medical Digest (Otorhinolaryngology)"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.112026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095\u20100616.2023.04.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882\u2010013\u20100341\u20104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.03.029"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12780"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.14148\/j.issn.1672\u20100482.2025.0637"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.88"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.730978"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008\u2010049X.2018.08.047"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.19347\/j.cnki.2096\u20101413.201835061"},{"issue":"02","key":"e_1_2_11_14_1","first-page":"171","article-title":"Application of LC\u2010MS Technology in the Analysis of Chinese Herbal Medicine","volume":"24","author":"Maimaitiaili T.","year":"2026","journal-title":"Central South Pharmacy"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24132453"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.10887"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.06.012"},{"issue":"05","key":"e_1_2_11_18_1","first-page":"409","article-title":"Study on the Anti\u2010Allergic Effect of Gallic Acid in Mice With Allergic Rhinitis","volume":"38","author":"Shen N.","year":"2022","journal-title":"Chinese Journal of Clinical Pharmacology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.10.052"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c02295"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.13406\/j.cnki.cyxb.003855"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674\u20103849.2002.02.001"},{"issue":"06","key":"e_1_2_11_23_1","first-page":"1157","article-title":"Integrative Dynamic PK\u2010PD Correlation Analysis and Its Application in Discovery of Pharmacodynamic Material Basis of Traditional Chinese Medicine","volume":"46","author":"Wang Y.","year":"2023","journal-title":"Drug Evaluation Research"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153565"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2024.09.010"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1503261"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2026.1761424"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2024.11582"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010025\u201009344\u20106"},{"issue":"06","key":"e_1_2_11_30_1","first-page":"640","article-title":"Simultaneous Determination of Protocatechuic Acid and Caffeic Acid in Anti\u2010Inflammatory Active Parts of Sauropus spatulifolius by HPLC","volume":"35","author":"Yu L.","year":"2020","journal-title":"West China Journal of Pharmaceutical Sciences"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010024\u201001056\u2010z"},{"issue":"4","key":"e_1_2_11_32_1","first-page":"94","article-title":"Identification of Chemical Constituents in Equisetum hyemale L. Based on UPLC\u2010Q\u2010Exactive\u2010Plus\u2010Orbitrap\u2010MS","volume":"47","author":"Zhang B.","year":"2025","journal-title":"Chemical Reagents"},{"issue":"11","key":"e_1_2_11_33_1","first-page":"210","article-title":"Research Progress on the Mechanism of Traditional Chinese Medicine Regulating MAPK Signaling Pathway in the Treatment of Sinusitis","volume":"43","author":"Zhang F.","year":"2025","journal-title":"Journal of Sichuan of Traditional Chinese Medicine"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.7501\/j.issn.0253\u20102670.2025.14.003"},{"issue":"08","key":"e_1_2_11_35_1","first-page":"1353","article-title":"Simultaneous Determination of Paeoniflorin and Linarin in Fangzhi Biyan Tablets by RRLC","volume":"36","author":"Zhang W.","year":"2013","journal-title":"Journal of Chinese Medicinal Materials"},{"issue":"27","key":"e_1_2_11_36_1","first-page":"130","article-title":"Efficacy and Safety Analysis of Xiangju Tablets Combined With n\u2010Acetylcysteine Aerosol Inhalation in the Treatment of Acute Sinusitis in Children","volume":"23","author":"Zhang Z.","year":"2025","journal-title":"Contemporary Medical Symposium"},{"issue":"04","key":"e_1_2_11_37_1","first-page":"276","article-title":"Protective Effect of Rosmarinic Acid on Oxidative Stress Reaction of Allergic Rhinitis Induced by PM2.5","volume":"21","author":"Zhou L.","year":"2021","journal-title":"Chinese Journal of Ophthalmology and Otorhinolaryngology"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmc.70615","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:30:23Z","timestamp":1789659023000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/bmc.70615"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70615","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"2026-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70615"}}