{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:48:24Z","timestamp":1791982104402,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060630"],"award-info":[{"award-number":["82060630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560565"],"award-info":[{"award-number":["81560565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Oxalis corniculata<\/jats:italic>\n                    <\/jats:styled-content>\n                    L. exhibits neuroprotection; however, its in\u00a0vivo molecular profiling remains unclear. An ultra\u2010high performance liquid chromatography\u2010electrospray ionization\u2010quadrupole\u2010time\u2010of\u2010flight high resolution mass spectrometry (UHPLC\u2010ESI\u2010Q\u2010TOF\u2010HRMS) was established to determine and quantify six\n                    <jats:italic>C<\/jats:italic>\n                    \u2010glycosyl flavonoids in the herb, namely swertisin, schaftoside, isoschaftoside, vitexin, isovitexin, and isoorientin. They were identified and confirmed in the aqueous extract of the herb with mass error less than 5\u2009ppm in HRMS. The founded UHPLC\u2010ESI\u2010Q\u2010TOF\u2010HRMS was optimized and validated for biological samples analysis, with coefficient of determination\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    greater than 0.998, matrix factor being near to 1, recoveries from 85.0% to 115.0% and relative standard deviation from 0.17% to 12.88%. Their simultaneous quantification for the first time by UHPLC\u2010ESI\u2010Q\u2010TOF\u2010HRMS indicated their contents to be from 47.7 to 455.5\u2009mg\/kg in the herb in dry weight. After a single oral administration of the saturated aqueous solution of the herb extract to rats, swertisin was typically quantified in rat brain, heart, liver, kidneys, lung, spleen, small intestine, bile, and excreta under multiple reaction monitoring. Schaftoside and isoschaftoside were quantitated in rat brain. Their in\u00a0vivo molecular profiling in rats was illustrated, especially their penetration of rat blood\u2013brain barrier. Totally 17 metabolites were identified in the biological samples.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70622","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:46:59Z","timestamp":1789717619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["UHPLC\u2010ESI\u2010Q\u2010TOF\u2010HRMS Quantitated Six\n                    <i>C<\/i>\n                    \u2010Glycosyl Flavonoids in\n                    <scp>\n                      <i>Oxalis corniculata<\/i>\n                    <\/scp>\n                    and Demonstrated Their Typical In\u00a0Vivo Molecular Profiling in Rats"],"prefix":"10.1002","volume":"40","author":[{"given":"Lijun","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmacy and Yunnan Provincial Key Laboratory of Pharmacology for Natural Medicines Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongmei","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Yunnan Provincial Key Laboratory of Pharmacology for Natural Medicines Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-0416","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Yunnan Provincial Key Laboratory of Pharmacology for Natural Medicines Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/sscp.70175"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.03.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29245829"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5227335"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4188"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.70106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmw147"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5892"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2025.05.023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.05.036"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10265-007-0132-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000155"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12132434"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26216632"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmaf028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2025.138429"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c04049"},{"issue":"4","key":"e_1_2_10_19_1","first-page":"611","article-title":"Chemical Constituents Analysis of Oxalis Corniculata L. Based on UPLC\u2010Q\u2010Exactive\u2010Plus\u2010Orbitrap\u2010MS","volume":"42","author":"Zhang B.","year":"2025","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02133-z"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3972"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14111352"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmc.70622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.70622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:14:03Z","timestamp":1791980043000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.70622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/bmc.70622"],"URL":"https:\/\/doi.org\/10.1002\/bmc.70622","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"2026-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70622"}}