{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:49:10Z","timestamp":1791982150371,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Yangxin Dingji Capsules (YXDJ), derived from Zhigancao Decoction, are used clinically for arrhythmia. Four D101 macroporous\u2010resin purification procedures involving different Asini Corii Colla incorporation modes and elution solvents were compared; the co\u2010decoction procedures additionally included centrifugation and filtration before resin purification. The unpurified preparation and four purified preparations were characterized by UPLC\u2010Q\u2010TOF\u2010MS\/MS and evaluated in a barium chloride\u2010induced rat arrhythmia model using electrocardiographic, biochemical, and histopathological indicators. Fifty\u2010five constituents were tentatively identified. The 60% ethanol\u2010eluted preparations CF1 and CF3 retained 52 and 51 constituents, respectively, whereas the water\u2010eluted preparations CF2 and CF4 retained 21 and 14. CF1 showed the highest Pearson correlation with YXDJ among the purified preparations (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.520), while CF3 had the highest five\u2010indicator comprehensive pharmacodynamic score among the purified preparations (CPS5\u2009=\u20093.540); unpurified YXDJ scored 3.827. Compared with the model group, CF3 significantly increased heart rate, shortened QRS duration, reduced serum lactate dehydrogenase, and increased Na\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATPase activity. Exploratory one\u2010component partial least\u2010squares variable\u2010importance and gray relational analyses generated a provisional list of 12 constituents for subsequent targeted quantification and pharmacological verification.\n                  <\/jats:p>","DOI":"10.1002\/bmc.70641","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:06:22Z","timestamp":1791896782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Chemical and Pharmacodynamic Evaluation of Different Purification Procedures for Yangxin Dingji Capsules"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2868-0763","authenticated-orcid":false,"given":"Xinyao","family":"Lu","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Centre of Hebei Province, College of Pharmacy Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei Provincial Technology Innovation Center for Quantitative Research and Application of Traditional Chinese Medicine  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Datong","family":"Li","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Centre of Hebei Province, College of Pharmacy Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei Provincial Technology Innovation Center for Quantitative Research and Application of Traditional Chinese Medicine  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6961-7024","authenticated-orcid":false,"given":"Zitan","family":"Hou","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Centre of Hebei Province, College of Pharmacy Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei Provincial Technology Innovation Center for Quantitative Research and Application of Traditional Chinese Medicine  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"An","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Centre of Hebei Province, College of Pharmacy Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Department of Chinese Materia Medica Hebei Institute for Drug and Medical Device Control  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjie","family":"Hou","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Centre of Hebei Province, College of Pharmacy Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei Provincial Technology Innovation Center for Quantitative Research and Application of Traditional Chinese Medicine  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Xue","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Processing Technology Innovation Centre of Hebei Province, College of Pharmacy Hebei University of Chinese Medicine  Shijiazhuang China"},{"name":"Hebei Provincial Technology Innovation Center for Quantitative Research and Application of Traditional Chinese Medicine  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan","family":"Xie","sequence":"additional","affiliation":[{"name":"Hebei Provincial Classical Formula Chinese Patent Medicine Pharmaceutical Preparation Technology Innovation Center Hebei Yongfeng Pharmaceutical Co., Ltd.  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