{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:05:22Z","timestamp":1790787922827,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A simple and sensitive method for the determination of nitrendipine in rat plasma was developed using high\u2010performance liquid chromatography (HPLC). The procedure involves extraction of nitrendipine in dichloromethane\/sodium hydroxide, followed by reversed phase HPLC using a Waters, Spherisorb ODS2 (250 \u00d7 4.6 mm, 5 \u00b5m) column and UV detection at 238 nm. The retention times of nitrendipine and internal standard (felodipine) were 5.0 min and 7.5 min, respectively. The calibration curves were linear over the range of 5 ng\/mL (lower limit of quantification, LOQ) to 200 ng\/mL for nitrendipine. The intra\u2010 and inter\u2010day coefficients of variation for all criteria of validation were less than 15% over the linearity range. The sensitivity and precision of the method were within the accepted limits (&lt; 15%) throughout the validation period. The present method was also successfully applied for the study of plasma pharmacokinetics of nitrendipine loaded solid lipid nanoparticles (SLN) in rats. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.761","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T06:59:27Z","timestamp":1169189967000},"page":"363-368","source":"Crossref","is-referenced-by-count":11,"title":["Development and validation of a reversed\u2010phase HPLC method for determination of nitrendipine in rat plasma: application to pharmacokinetic studies"],"prefix":"10.1002","volume":"21","author":[{"given":"Vinay Kumar","family":"Venishetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekar","family":"Durairaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna","family":"Sistla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudhan Rao","family":"Yamsani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash V.","family":"Diwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2005.04.028"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(85)80054-2"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200131202"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(01)00600-6"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1983.tb02734.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(03)00129-8"},{"key":"e_1_2_1_8_1","first-page":"167","article-title":"Nitrendipine: a new dihydropyridine calcium channel antagonist for the treatment of hypertension","volume":"4","author":"Santiago TM","year":"1990","journal-title":"Annals of Pharmacotherapy"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83929-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(00)00489-1"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.761","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:54:25Z","timestamp":1760050465000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,19]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1002\/bmc.761"],"URL":"https:\/\/doi.org\/10.1002\/bmc.761","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,19]]}}}