{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:55:46Z","timestamp":1791179746764,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diesel exhaust particulate extract (DEPE) was obtained from diesel exhaust particulates with Soxhlet extraction using dichloromethane. After separating DEPE into 11 fractions by liquid\u2013liquid extraction, the neutral fraction (N) showed anti\u2010estrogenic activity and the weak acid (phenol) fraction (WA<jats:sub>P<\/jats:sub>) showed estrogenic and anti\u2010estrogenic activities by a yeast two\u2010hybrid assay system expressing human estrogen receptor <jats:italic>\u03b1<\/jats:italic>. Both fractions were thoroughly fractionated by silica gel column chromatography and reversed\u2010phase HPLC. In the WA<jats:sub>P<\/jats:sub> fraction, 3\u2010methyl\u20104\u2010nitrophenol and 2,6\u2010dimethyl\u20104\u2010nitrophenol were identified by LC\u2010MS\/MS as estrogenic compounds. This is the first study to identify 2,6\u2010dimethyl\u20104\u2010nitrophenol in DEPE and the first study to show that it is an estrogenic compound. In the N fraction, 1\u2010hydroxypyrene was also identified by LC\u2010MS\/MS as an anti\u2010estrogenic compound. 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