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Here, we have investigated whether quinic\u2010 and chlorogenic\u2010acid\u2010derived Carbon Quantum Dots (QACQDs and ChACQDs, respectively) protect against a (pesticide) paraquat\u2010insult model of PD. Our results indicated that both types of CQDs intervened in the soluble\u2010to\u2010toxic transformation of the amyloid\u2010forming model protein Hen Egg White Lysozyme (HEWL). Furthermore, QACQDs and ChACQDs demonstrated antioxidant activity while remaining biocompatible in a human neuroblastoma\u2010derived cell line (SH\u2010SY5Y) up to 5\u00a0mg\/ml and protected the cell line from the environmental neurotoxicant (paraquat). Importantly, both CQDs were found to protect dopaminergic neuronal ablation in a paraquat model of Parkinson's disease using the nematode <jats:italic>C<\/jats:italic>. <jats:italic>elegans<\/jats:italic>. Our results are significant because both plant\u2010derived organic acids cross the blood\u2013brain barrier, making them attractive for developing CQD architectures. Furthermore, since the synthesis of these CQDs was performed using green chemistry methods from precursor acids that cross the BBB, these engineered bionanomaterial platforms are tantalizing candidates for preventing neurodegenerative disorders associated with exposure to environmental neurotoxicants.<\/jats:p>","DOI":"10.1002\/bmm2.12072","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T10:59:55Z","timestamp":1706353195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Development of novel carbon\u2010based biomedical platforms for intervention in xenotoxicant\u2010induced Parkinson's disease onset"],"prefix":"10.1002","volume":"2","author":[{"given":"Jyotish","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Texas at El Paso (UTEP)  El Paso USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Varela\u2010Ramirez","sequence":"additional","affiliation":[{"name":"The Department of Biological Sciences Border Biomedical Research Center The Cellular Characterization and Biorepository Core Facility The University of Texas at El Paso (UTEP)  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-5228","authenticated-orcid":false,"given":"Mahesh","family":"Narayan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Texas at El Paso (UTEP)  El Paso USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"124","volume":"9","author":"Chan M. 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