{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:03:01Z","timestamp":1757311381647,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim was to evaluate the regenerative effect of epineural injection of rat <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">rASC<\/jats:styled-content>s) in three different settings of acute and chronic compression in a rat sciatic nerve model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute compression (60\u00a0s) with a vessel clamp over a distance of 1\u00a0mm (group 1) or 10\u00a0mm (group 2), as well as chronic compression with a permanent remaining, nonabsorbable polymeric clip over a distance of 1\u00a0mm (group 3) was performed. Depending on the group, either 5\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> <jats:styled-content style=\"fixed-case\">rASC<\/jats:styled-content>s or the same volume (25\u00a0\u03bcl) of culture medium (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) was injected with a 30G needle in the epineurium at the time of compression. Outcome measures were functional gait evaluations, imaging analysis, histomorphometric analyses, and muscle weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rats in group 2 had a better function than those with group 1 at one and especially at 2\u00a0weeks. After 4\u00a0weeks however, almost all rats were close to a normal function. There was a similar Muscle Weight Ratio (<jats:styled-content style=\"fixed-case\">MWR<\/jats:styled-content>) after 2\u00a0weeks in all groups, whereas after 4\u00a0weeks, the <jats:styled-content style=\"fixed-case\">MWR<\/jats:styled-content> in group 3 was lower compared with group 1 and 2. Histomorphometric analysis showed a better myelination in group 1 &amp; 2 compared to group 3 after 4\u00a0weeks. <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>s have a beneficial effect on myelin thickness (G\u2010Ratio).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We successfully evaluated the regenerative effect of epineural injection of <jats:styled-content style=\"fixed-case\">rASC<\/jats:styled-content>s in three different settings of acute and chronic compression. However, there were no significant differences in outcomes between the <jats:styled-content style=\"fixed-case\">ASC<\/jats:styled-content>\u2010treated groups and control groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1027","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T17:51:16Z","timestamp":1529430676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epineural adipose\u2010derived stem cell injection in a sciatic rodent model"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-1951","authenticated-orcid":false,"given":"Elisabeth A.","family":"Kappos","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"},{"name":"Department of Neuropathology Institute of Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Baenziger\u2010Sieber","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"},{"name":"Department of Neuropathology Institute of Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-9690","authenticated-orcid":false,"given":"Mathias","family":"Tremp","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"},{"name":"Department of Neuropathology Institute of Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E.","family":"Engels","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"},{"name":"Department of Neuropathology Institute of Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Thommen","sequence":"additional","affiliation":[{"name":"Basel Institute for Clinical Epidemiology and Biostatistics University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lima","family":"Sprenger","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn M.","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schaeren","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery University Hospital of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Felix","family":"Kalbermatten","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive, Aesthetic and Hand Surgery University Hospital Basel  Basel Switzerland"},{"name":"Department of Neuropathology Institute of Pathology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"168","article-title":"Thirty minutes of low intensity electrical stimulation promotes nerve regeneration after sciatic nerve crush injury in a rat model","volume":"110","author":"Alrashdan M. 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