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We previously demonstrated that Gunn rats with hyperbilirubinemia show congenital gliosis and schizophrenia\u2010like behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As it has been suggested that major depression involves glial activation associated with neuroinflammation, we examined whether Gunn rats show depression\u2010like behavior using the forced swimming test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>) and the tail suspension test (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>). In addition, we quantitatively evaluated both microgliosis and astrogliosis in the hippocampus of Gunn rats using immunohistochemistry analysis of the microglial marker ionized calcium\u2010binding adaptor molecule (Iba) 1 and the astrocytic marker S100B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> showed that immobility time of Gunn rats was significantly longer than that of normal control Wistar rats, indicating that Gunn rats are somewhat helpless, a sign of depression\u2010like behavior. In the quantification of immunohistochemical analysis, Iba1immunoreactivity in the dentate gyrus (<jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content>), cornu ammonis (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>) 1, and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 and the number of Iba1\u2010positive cells in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 were significantly increased in Gunn rats compared to Wistar rats. S100B immunoreactivity in the <jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CA<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 and the number of S100B\u2010positive cells in the <jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 were significantly increased in Gunn rats compared to Wistar rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that both microglia and astrocyte are activated in Gunn rats and their learned helplessness could be related to glial activation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1028","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T19:45:38Z","timestamp":1530215138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test"],"prefix":"10.1002","volume":"8","author":[{"given":"Ryosuke","family":"Arauchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Shimane University  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-0417","authenticated-orcid":false,"given":"Sadayuki","family":"Hashioka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Shimane University  Izumo 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