{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:11:19Z","timestamp":1791443479746,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81200884 and 81571136"],"award-info":[{"award-number":["81200884 and 81571136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>There is no well\u2010recognized biomarker for accurately predicting outcome in the presence of moyamoya disease (MMD<\/jats:styled-content>), a progressive occlusive cerebrovascular disease of the internal carotid arteries or their branches. The aim of this study was to investigate the presence of endothelial progenitor cells (EPC<\/jats:styled-content>s) and circulating endothelial cells (CEC<\/jats:styled-content>s) in MMD<\/jats:styled-content> and correlate the findings with clinical features.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with MMD<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a066) were compared with healthy controls (n<\/jats:italic>\u00a0=\u00a081). Blood samples were obtained from an antecubital vein and analyzed using flow cytometry. EPC<\/jats:styled-content>s were defined as CD<\/jats:styled-content>31+<\/jats:sup>CD<\/jats:styled-content>45dim<\/jats:sup>CD<\/jats:styled-content>34br<\/jats:sup>CD<\/jats:styled-content>133+<\/jats:sup> and CEC<\/jats:styled-content>s as CD<\/jats:styled-content>31br<\/jats:sup>CD<\/jats:styled-content>45\u2212<\/jats:sup>CD<\/jats:styled-content>34dim<\/jats:sup>CD<\/jats:styled-content>133\u2212<\/jats:sup>. Univariate and multivariate linear regression analyses were carried out.<\/jats:p><\/jats:sec>Results<\/jats:title>The CEC<\/jats:styled-content> counts were significantly higher in the patients than in the controls (p<\/jats:italic>\u00a0=\u00a00.008). In multivariate analysis, EPC<\/jats:styled-content> counts were independently associated with age of patients with MMD<\/jats:styled-content> (p<\/jats:italic>\u00a0=\u00a00.049) and CEC<\/jats:styled-content> counts were independently negatively associated with concomitant disease such as hypertension, diabetes mellitus, and coronary heart disease (p<\/jats:italic>\u00a0=\u00a00.034).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This is the first study to investigate the presence of CEC<\/jats:styled-content>s in the plasma of patients with MMD<\/jats:styled-content>, and the amount of CEC<\/jats:styled-content>s was negatively correlated with concomitant disease in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1035","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T05:33:52Z","timestamp":1535088832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Circulating endothelial progenitor cells and endothelial cells in moyamoya disease"],"prefix":"10.1002","volume":"8","author":[{"given":"Xiang\u2010Yang","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Center for Cerebral Vascular Disease PLA 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Na","family":"Fan","sequence":"additional","affiliation":[{"name":"Center of Interventional Radiology for Oncology 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Lab of Tumor Molecular 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Center for Cerebral Vascular Disease PLA 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Center for Cerebral Vascular Disease PLA 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Center for Cerebral Vascular Disease PLA 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Lab of Tumor Molecular 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3586-4653","authenticated-orcid":false,"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Center for Cerebral Vascular Disease PLA 307th Hospital, PLA Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6887"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00278"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.964"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3964"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016662039"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01760"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986732304160204181543"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3313"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1971"},{"key":"e_1_2_7_11_1","first-page":"163","article-title":"Circulating endothelium as an indicator of vascular injury","volume":"40","author":"Bouvier C. A.","year":"1970","journal-title":"Thrombosis et Diathesis Haemorrhagica"},{"issue":"4","key":"e_1_2_7_12_1","first-page":"698","article-title":"Circulating endothelial cells in pulmonary hypertension","volume":"90","author":"Bull T. M.","year":"2003","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200105)44:5<1203::AID-ANR204>3.0.CO;2-C"},{"issue":"23","key":"e_1_2_7_14_1","first-page":"27","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon J.","year":"2004","journal-title":"Circulation"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.065004215.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.111"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.05.016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2014-0307"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00300.x"},{"issue":"9","key":"e_1_2_7_20_1","first-page":"531","article-title":"Circulating endothelial cells: Markers of vascular dysfunction","volume":"51","author":"Goon P. K.","year":"2005","journal-title":"Clinical Laboratory"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05592"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000124603.46777.EB"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(73)90014-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.67"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.090203.104149"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20040"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01627"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22228"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01739"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00906-5"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2015.57.6.436"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116635"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169714"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142295.85740.98"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.529420"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"issue":"4","key":"e_1_2_7_37_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/7434","article-title":"Ischemia\u2010 and cytokine\u2010induced mobilization of bone marrow\u2010derived endothelial progenitor cells for neovascularization","volume":"5","author":"Takahashi T.","year":"1999","journal-title":"Nature Medicine"},{"key":"e_1_2_7_38_1","first-page":"37","article-title":"Hypogenesis of bilateral internal carotid arteries","volume":"9","author":"Takeuchi K.","year":"1957","journal-title":"No To Shinkei"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00598.x"},{"issue":"1","key":"e_1_2_7_40_1","first-page":"30","article-title":"Level of circulating endothelial cells and expression of nuclear factor kappa beta of human's peripheral blood mononuclear cells in subjects with certain conditions","volume":"46","author":"Wihastuti T. A.","year":"2014","journal-title":"Acta Medica Indonesiana"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.123782"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000074569.65127.26"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12269-6"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.1"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.1035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:51:55Z","timestamp":1695019915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/brb3.1035"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1035","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"2017-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01035"}}