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Clinical scales, tremor frequency and amplitude as measured by accelerometry were correlated with<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>patients demonstrated mean (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) and radial diffusivity (<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in nonmotor regions including the inferior fronto\u2010occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>in extensive<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>measures and clinical rating scales scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results show that<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>\u2010related diffusion<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>deficits in<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1039","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T13:24:46Z","timestamp":1530537886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["White matter measures correlate with essential tremor severity\u2014A pilot diffusion tensor imaging study"],"prefix":"10.1002","volume":"8","author":[{"given":"Igor","family":"Nestrasil","sequence":"first","affiliation":[{"name":"Division of Clinical Behavioral Neuroscience Department of Pediatrics University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-4280","authenticated-orcid":false,"given":"Alena","family":"Svatkova","sequence":"additional","affiliation":[{"name":"Division of Clinical Behavioral Neuroscience Department of Pediatrics University of Minnesota Minneapolis Minnesota"},{"name":"Department of Medicine III, Clinical Division of Endocrinology and Metabolism Medical University of Vienna Vienna Austria"},{"name":"Multimodal and Functional Neuroimaging Research Group Central European Institute of Technology Masaryk University Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle D.","family":"Rudser","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravishankar","family":"Chityala","sequence":"additional","affiliation":[{"name":"Minnesota Supercomputing Institute University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Wakumoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Behavioral Neuroscience Department of Pediatrics University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryon A.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Bedna\u0159\u00edk","sequence":"additional","affiliation":[{"name":"Multimodal and Functional Neuroimaging Research Group Central European Institute of Technology Masaryk University Brno Czech Republic"},{"name":"Department of Radiology Center for Magnetic Resonance Research University of Minnesota Minneapolis Minnesota"},{"name":"High Field MR Centre Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Tuite","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Psychology Department Sun Yet\u2010Sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalaf","family":"Bushara","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Minnesota Minneapolis Minnesota"},{"name":"Neurology Service Veterans Affairs Medical Center Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.011"},{"key":"e_1_2_9_3_1","unstructured":"Andersson J. 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