{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:08:04Z","timestamp":1792462084804,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3\u20100019"],"award-info":[{"award-number":["P3\u20100019"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although Huntington's disease (HD) is a disease of the central nervous system, HD mortality surveys indicate heart disease as a major cause of death. Cardiac dysfunction in HD might be a primary consequence of peripherally expressed mutant huntingtin or secondary to either a general decline in health or the onset of neurological dysfunction. The aim of the study was to clarify the heart muscle involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We measured conventional and advanced resting ECG indices. Thirty<jats:styled-content>\u2010<\/jats:styled-content>one subjects with a confirmed huntingtin gene mutation and 31 age\u2010 and gender\u2010matched controls were included. The HD subjects were divided into four groups based on their Unified Huntington Disease Rating Scale (UHDRS) motor score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected changes in advanced ECG variables connected with electrical ventricular remodeling (<jats:italic>t<\/jats:italic> test, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The increase in the unexplained part of both QT variability and the standard deviation of normal\u2010to\u2010normal QT intervals, presumably reflecting beat\u2010to\u2010beat changes in repolarization, was most pronounced. Further, both variables correlated with the product of the cytosine\u2013adenine\u2013guanine (CAG) triplets\u2019 repeat length and the subjects\u2019 age (CAP), the former <jats:italic>R<\/jats:italic>\u00a0=\u00a00.423 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018) and the latter <jats:italic>R<\/jats:italic>\u00a0=\u00a00.499 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). There was no correlation between the CAP score and any of variables representing autonomic nervous system activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both autonomic nervous system dysfunction and cardiac electrical remodeling are present in patients with HD. The changes in advanced ECG variables observed in the study evolve with HD progression. The increased values of QT unexplained variability may be a marker of temporal inhomogeneity in ventricular repolarization associated with malignant ventricular arrhythmias.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1077","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T11:34:39Z","timestamp":1532086479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evidence of cardiac electrical remodeling in patients with Huntington disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-7694","authenticated-orcid":false,"given":"Ksenija","family":"Cankar","sequence":"first","affiliation":[{"name":"Faculty of medicine Institute of Physiology University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziva","family":"Melik","sequence":"additional","affiliation":[{"name":"Faculty of medicine 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