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Brain network disruptions in AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying an apolipoprotein (APOE)\u2010\u03b54 allele is a genetic risk for AD, associated with increased amyloid deposition. We studied whether APOE\u2010\u03b54 carriership is associated with EC disruptions in cognitively normal individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 261 healthy middle\u2010aged to older adults (mean age 56.6\u00a0years) were divided into high\u2010risk (APOE\u2010\u03b54 carriers) and low\u2010risk (noncarriers) groups. EC was computed from resting\u2010state functional MRI data. Clusters of between\u2010group differences were assessed with a permutation\u2010based method. Correlations between cluster mean EC with brain volume, CSF biomarkers, and psychological test scores were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decreased EC in the visual cortex was associated with APOE\u2010\u03b54 carriership, a genetic risk factor for AD. EC differences were correlated with age, CSF amyloid levels, and scores on the trail\u2010making and 15\u2010object recognition tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the APOE\u2010\u03b54 genotype affects brain connectivity in regions previously found to be abnormal in AD as a sign of very early disease\u2010related pathology. These differences were too subtle in healthy elderly to use EC for single\u2010subject prediction of APOE genotype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1080","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T04:10:14Z","timestamp":1534997414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Functional brain network centrality is related to APOE genotype in cognitively normal elderly"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8197-0118","authenticated-orcid":false,"given":"Alle Meije","family":"Wink","sequence":"first","affiliation":[{"name":"Department of Radiology, Nuclear Medicine and PET Research Neuroscience Campus Amsterdam VU University Medical Centre  Amsterdam The 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