{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:28:30Z","timestamp":1775730510482,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["MZ \u010cR\u2013 RVO, FNBr 65269705."],"award-info":[{"award-number":["MZ \u010cR\u2013 RVO, FNBr 65269705."]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Multiple sclerosis (MS) often occurs in young women and the effect of obstetric anesthesia\/analgesia on the disease is poorly understood. No previous study has investigated the course of the disease in women in labor in the Czech Republic. The aim of this study was to evaluate the occurrence or absence of relapses in the 6\u2010month postpartum period in MS parturients with and without obstetric anesthesia\/analgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively studied all deliveries (<jats:italic>n<\/jats:italic>\u00a0=\u00a058,455) at the University Hospital Brno from 2004 to 2013 and identified those of the women with an <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 code G35 (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) recorded anytime in their medical history (<jats:italic>n<\/jats:italic>\u00a0=\u00a0428). We included only deliveries of women with confirmed diagnosis at the time of labor (<jats:italic>n<\/jats:italic>\u00a0=\u00a070). Statistical analysis was performed using the Fischer Exact Test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 70 deliveries of 65 women, including 45 vaginal deliveries and 25 Cesarean deliveries (16 under general anesthesia, 8 with epidural anesthesia and 1 with spinal anesthesia). Epidural obstetric analgesia was performed in 11 deliveries. There was no statistically significant difference in relapses between the vaginal delivery group (<jats:italic>n<\/jats:italic>\u00a0=\u00a015; 33%) and Cesarean section group (<jats:italic>n<\/jats:italic>\u00a0=\u00a010; 40%), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.611.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neither delivery mode (vaginal vs Caesarean) nor type of obstetric anesthesia\/analgesia was found to have any impact on the course of MS at 6\u00a0months postpartum in women with this condition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1082","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T03:48:51Z","timestamp":1532576931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Obstetric anesthesia\/analgesia does not affect disease course in multiple sclerosis: 10\u2010year retrospective cohort study"],"prefix":"10.1002","volume":"8","author":[{"given":"Hana","family":"Harazim","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Medical Faculty of Masaryk University University Hospital Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"\u0160toura\u010d","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical Faculty of Masaryk University University Hospital Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Jank\u016f","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Medical Faculty of Masaryk University University Hospital Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Zelinkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analysis Medical Faculty of Masaryk University  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Medical Faculty of Masaryk University University Hospital Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Dufek","sequence":"additional","affiliation":[{"name":"First Department of Neurology Medical Faculty of Masaryk University St Anne's University Hospital  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-5926","authenticated-orcid":false,"given":"Petr","family":"\u0160toura\u010d","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesiology and Intensive Care Medicine Medical Faculty of Masaryk University University Hospital Brno  Brno Czech 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