{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:50:45Z","timestamp":1768251045460,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC09\u201010\u201011\u201012\u201013\u201014\/A"],"award-info":[{"award-number":["RC09\u201010\u201011\u201012\u201013\u201014\/A"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009880","name":"Regione Lazio","doi-asserted-by":"publisher","award":["PAMINA project"],"award-info":[{"award-number":["PAMINA project"]}],"id":[{"id":"10.13039\/501100009880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims of the study<\/jats:title><jats:p>We aimed at investigating the psychiatric profile of the three motor subtypes of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (akinetic\u2010rigid, tremor\u2010dominant, and mixed) in de novo drug\u2010na\u00efve patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010eight patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, divided into 39 akinetic\u2010rigid (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>), seven mixed (<jats:styled-content style=\"fixed-case\">MIX<\/jats:styled-content>), and 22 tremor\u2010dominant (<jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>) patients underwent a complete assessment of psychiatric, cognitive, and motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were found among groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that a differentiation of the psychiatric symptoms associated with specific motor subtypes of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> is not detectable in de novo drug\u2010na\u00efve patients. Previous evidence that emerges later along the disease progression may be a consequence of the dopaminergic and nondopaminergic damage increase.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1094","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T16:12:13Z","timestamp":1535645533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Psychiatric profile of motor subtypes of de novo drug\u2010na\u00efve Parkinson's disease patients"],"prefix":"10.1002","volume":"8","author":[{"given":"Francesca","family":"Assogna","sequence":"first","affiliation":[{"name":"Centro Fermi \u2010 Museo Storico della Fisica e Centro Studi e Ricerche \u201cEnrico Fermi\u201d Rome Italy"},{"name":"Fondazione Santa Lucia IRCCS Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clelia","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Fondazione Santa Lucia IRCCS 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