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Studies of twins and families indicate an important role for genetic factors in ET development. There are substantial overlaps between ET and Parkinson's disease (PD). The aim of this study was to examine the possible roles of genetic variants in ET development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 200 Han Chinese ET patients and 432 ethnically matched normal controls were enrolled, and genetic analysis of 23 variants in 15 genes was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Genotypic and allelic frequencies of the melanocortin 1 receptor gene (<jats:italic>MC1R<\/jats:italic>) variant rs34090186 showed statistically significant differences in ET patients and controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027 and 0.028, odds ratio\u00a0=\u00a02.789 and 2.744, 95% confidence interval: 1.084\u20137.179 and 1.075\u20137.005). No statistically significant difference was revealed in either genotypic or allelic distributions of other variants or haplotypes (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The discrepancies found in this study indicate the variant rs34090186 in the <jats:italic>MC1R<\/jats:italic> gene, some variants of which were reported to be related to increased risk of PD and melanoma, may play a risk role in ET, confirming a potential association between ET and PD. Evidence supporting ET\u2010PD link will continue to accumulate and improve our understanding of any underlying mechanisms for both disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1100","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T10:54:40Z","timestamp":1536144880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systematic analysis of genetic variants in patients with essential tremor"],"prefix":"10.1002","volume":"8","author":[{"given":"Lamei","family":"Yuan","sequence":"first","affiliation":[{"name":"Center for Experimental Medicine The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nursing Education The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-4352","authenticated-orcid":false,"given":"Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine The Third Xiangya Hospital, Central South University Changsha China"},{"name":"Department of Neurology The Third Xiangya Hospital, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1073\/pnas.98.2.581","article-title":"High\u2010throughput development and characterization of a genomewide collection of gene\u2010based single nucleotide polymorphism markers by chip\u2010based matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight mass spectrometry","volume":"98","author":"Buetow K. 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