{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:27:32Z","timestamp":1791570452810,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Aimee Stacey Memorial and Ignacy Burnett Bequests"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many people with ALS have been suggested to have a \u201cnice\u201d personality, but most ALS personality studies to date have had limited numbers of participants and have not taken into account personality differences between genders. We used Big Five Inventory data obtained from an online questionnaire looking for risk factors for ALS to investigate personality traits in large numbers of people with ALS and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 741 questionnaire respondents aged 40\u00a0years and over indicated the extent to which they agreed with each of the 44 Big Five Inventory statements. Respondents were 339 with ALS (212 male, 127 female) who responded to the statements as they applied to them before their diagnosis and 402 controls (120 male, 282 female). Unpaired <jats:italic>t<\/jats:italic> tests with 95% confidence intervals were used to compare mean values of Big Five\u2010factor scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Female respondents taken together had higher mean scores for Agreeableness and Neuroticism than all male respondents. Male ALS respondents had higher mean scores than male controls for Conscientiousness and Extraversion. Female ALS respondents had higher mean scores than female controls for Agreeableness, Conscientiousness, and Extraversion, and a lower score for Neuroticism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many people with ALS have personality traits that are likely to underlie the perception they are particularly \u201cnice.\u201d This raises the possibility that genetic polymorphisms that influence personality could play a role in ALS. Furthermore, different personality traits could underlie lifestyle choices that are currently thought to be risk factors for ALS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1119","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:31:45Z","timestamp":1537579905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Are people with amyotrophic lateral sclerosis (ALS) particularly nice? An international online case\u2013control study of the Big Five personality factors"],"prefix":"10.1002","volume":"8","author":[{"given":"Jane A.","family":"Parkin Kullmann","sequence":"first","affiliation":[{"name":"The Stacey Motor Neuron Disease Laboratory, Discipline of Pathology The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Hayes","sequence":"additional","affiliation":[{"name":"Forensic Psychology, Sydney Medical School The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-7273","authenticated-orcid":false,"given":"Roger","family":"Pamphlett","sequence":"additional","affiliation":[{"name":"The Stacey Motor Neuron Disease Laboratory, Discipline of Pathology The University of Sydney Sydney New South Wales Australia"},{"name":"Department of Neuropathology Royal Prince Alfred Hospital Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26055"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c1df48"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482960903384283"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197003000-00002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14020126"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820510012004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-197709000-00003"},{"key":"e_1_2_6_10_1","first-page":"114","volume-title":"Handbook of Personality: Theory and Research","author":"John O. 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