{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:08:30Z","timestamp":1788934110276,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202435"],"award-info":[{"award-number":["81202435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A030307025"],"award-info":[{"award-number":["2014A030307025"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Total saponins from the leaves of\n                      <jats:italic>Panax notoginseng<\/jats:italic>\n                      saponins (SLPN) could inhibit development of depression, but the underlying mechanisms remains unclear. This study aimed to address the roles of circular RNAs in depression inhibition by SLPN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The mouse chronic unpredictable mild stress (CUMS) model was established, which were confirmed by mouse weight, forced swimming test (FST) and tail suspension test (TST). Effects of SLPN on depression were evaluated in CUMS through these same assays. Circular RNA profiles in mouse ventral medial prefrontal cortex (VMPC) and hippocampus of CUMS mice were determined by high\u2010through sequencing, followed by confirmation via qRT\u2010PCR. Overexpression of mmu_circ_0001223 was done by transfection of PC12 cell through lentiviral system. Protein abundances of cAMP response element binding protein 1(CREB1) and brain\u2010derived neurotrophic factor (BDNF) were evaluated by western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mouse body weight, immobility time in FST and immobility time in TST of CUMS mice were significantly recovered by SLPN treatment. A large number of circular RNAs were differentially expressed in the ventral medial prefrontal cortex (VMPC) and hippocampus tissues of CUMS mice. Among them, mmu_circ_0001223 expression was greatly decreased in CUMS mice, but significantly elevated by SLPN treatment. The protein levels of CREB1 and BDNF were also remarkably promoted in CUMS mice by treatment of SLPN. Overexpression of mmu_circ_0001223 enhanced CREB1 and BDNF protein levels in PC12 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SLPN regulate the expression of large number circular RNAs in CUMS mice, which might be important mediators of SLPN's anti\u2010depression effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1127","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T10:05:31Z","timestamp":1539079531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Total saponins from the leaves of\n                    <i>Panax notoginseng<\/i>\n                    \u00a0inhibit depression on mouse chronic unpredictable mild stress model by regulating circRNA expression"],"prefix":"10.1002","volume":"8","author":[{"given":"Hualin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Lingnan Normal University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Lingnan Normal University Zhanjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangdong Medical Laboratory Animal Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifan","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences South\u2010central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-8757","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences South\u2010central University for Nationalities Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.12.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-151"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3304"},{"issue":"6","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1139\/jpn.0441","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"Campbell S.","year":"2004","journal-title":"Journal of Psychiatry & Neuroscience Jpn"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30385-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111415735"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.07.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0406"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002055"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.11.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071043098"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2016.1255398"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07931-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01902.x"},{"issue":"12","key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1177\/0306624X13511040","article-title":"Diagnostic and statistical manual of mental disorders: Fifth edition; (DSM\u20105)","volume":"57","author":"Juki\u0107 V.","year":"2013","journal-title":"International Journal of Offender Therapy & Comparative Criminology"},{"issue":"2","key":"e_1_2_8_17_1","first-page":"472","article-title":"Circular RNAs in cancer: Novel insights into origins, properties, functions and implications","volume":"5","author":"Le Y.","year":"2015","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7372"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3469"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.01.004"},{"issue":"8057","key":"e_1_2_8_21_1","first-page":"53","article-title":"Mini review: Circular RNAs as potential clinical biomarkers for disorders in the central nervous system","volume":"7","author":"Lu D.","year":"2016","journal-title":"Frontiers in Genetics"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.08.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68405-5"},{"issue":"5","key":"e_1_2_8_24_1","first-page":"Unit 5.65","article-title":"Models of depression: Unpredictable chronic mild stress in mice","volume":"5","author":"Nollet M.","year":"2013","journal-title":"Current Protocols in Pharmacology"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90516-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.794783"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8526"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.03.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2008.10.014"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1008457"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw075"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0801-3"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.11.014"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.009"},{"key":"e_1_2_8_35_1","first-page":"1","article-title":"The differential expression of novel circular RNAs in an acute lung injury rat model caused by smoke inhalation","volume":"11","author":"Ye Z.","year":"2017","journal-title":"Journal of Physiology & Biochemistry"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.10.018"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.03.007"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.1127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:08:36Z","timestamp":1775243316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/brb3.1127"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1127","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"2018-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01127"}}