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No. 30.6018\/2013\u20106"],"award-info":[{"award-number":["CNPq Proc. No. 30.6018\/2013\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008532","name":"Universidade Federal do Rio Grande do Norte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008532","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The common marmoset (<jats:italic>Callithrix jacchus<\/jats:italic>), a small New World monkey, has been widely used as a biological model in neuroscience to elucidate neural circuits involved in cognition and to understand brain dysfunction in neuropsychiatric disorders. In this regard, the availability of gene expression data derived from next\u2010generation sequencing (NGS) technologies represents an opportunity for a molecular contextualization. Sexual dimorphism account for differences in diseases prevalence and prognosis. Here, we explore sex differences on frontal cortex of gene expression in common marmoset's adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gene expression profiles in six different tissues (cerebellum, frontal cortex, liver, heart, and kidney) were analyzed in male and female marmosets. To emphasize the translational value of this species for behavioral studies, we focused on sex\u2010biased gene expression from the frontal cortex of male and female in common marmosets and compared to humans (<jats:italic>Homo sapiens<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we found that frontal cortex genes whose expression is male\u2010biased are conserved between marmosets and humans and enriched with \u201chouse\u2010keeping\u201d functions. On the other hand, female\u2010biased genes are more related to neural plasticity functions involved in remodeling of synaptic circuits, stress cascades, and visual behavior. Additionally, we developed and made available an application\u2014the CajaDB\u2014to provide a friendly interface for genomic, expression, and alternative splicing data of marmosets together with a series of functionalities that allow the exploration of these data. CajaDB is available at cajadb.neuro.ufrn.br.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data point to differences in gene expression of male and female common marmosets in all tissues analyzed. In frontal cortex, female\u2010biased expression in synaptic plasticity, stress, and visual processing might be linked to biological and behavioral mechanisms of this sex. Due to the limited sample size, the data here analyzed are for exploratory purposes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1148","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T04:10:44Z","timestamp":1540959044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex\u2010biased gene expression in the frontal cortex of common marmosets (<i>Callithrix jacchus<\/i>) and potential behavioral correlates"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6196-0046","authenticated-orcid":false,"given":"Viviane Brito","family":"Nogueira","sequence":"first","affiliation":[{"name":"Health Sciences Graduate Program Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-4951","authenticated-orcid":false,"given":"Danilo Oliveira","family":"Imparato","sequence":"additional","affiliation":[{"name":"Bioinformatics Multidisciplinary Environment Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro Jos\u00e9","family":"de Souza","sequence":"additional","affiliation":[{"name":"Brain Institute, Bioinformatics Multidisciplinary Environment Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-0418","authenticated-orcid":false,"given":"Maria Bernardete Cordeiro","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Brain Institute and Health Sciences Graduate Program Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"261","article-title":"Adaptations to subordinate status in female marmoset monkeys","volume":"119","author":"Abbott D. 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