{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:47:46Z","timestamp":1782139666645,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Program, Science and Technology Department of Sichuan Province in China","award":["NO.2017SZ0007"],"award-info":[{"award-number":["NO.2017SZ0007"]}]},{"name":"Key Research and Development Program, Science and Technology Department of Sichuan Province in China","award":["NO.2018JY0164"],"award-info":[{"award-number":["NO.2018JY0164"]}]},{"name":"Universal Application Program, Health and Family Planning Commission of Sichuan Province in China","award":["17PJ084"],"award-info":[{"award-number":["17PJ084"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate age\u2010specific clinical characteristics in patients aged &gt;60\u00a0years with large hemispheric infarction (LHI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled consecutive patients with LHI. Patients were divided into two groups: \u226460 vs. &gt;60\u00a0years, and demographics, vascular risk factors, clinical feature, in\u2010hospital treatment, 3\u2010month mortality, and unfavorable outcome (defined as a mRS score of 4\u20136) rate were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 256 cases included, 140 (54.7%) were older than 60\u00a0years. Compared with the younger, the older patients had higher rates of hypertension (66.4% vs. 31.0%), coronary heart disease (19.3% vs. 2.6%), atrial fibrillation (53.6% vs. 31.0%; all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), more history of stroke (21.4% vs. 5.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), less history of rheumatic heart disease (16.4% vs. 30.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), and alcohol consumption (12.1% vs. 21.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.043). Cardio\u2010embolism is the most common stroke etiology regardless of age (55.7% and 38.8%, respectively). Furthermore, the elderly less frequently received decompressive hemicraniectomy (4.3% vs. 15.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005) and mechanical ventilation (7.9% vs. 16.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035) and had a higher frequency of stroke\u2010related complication (83.6% vs. 66.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). A total of 26 (18.6%) older patients and 15 (12.9%) younger patients died during hospitalization (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.221), and 59 (42.1%) older patients and 35 (30.2%) younger patients died at 3\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.061). Patient aged &gt;60\u00a0years had significantly higher unfavorable outcome rate at 3\u00a0months (adjusted odds ratio, OR 4.30, 95% confidence interval [CI] 2.08\u20138.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05]. However, older age is not independently associated with 3\u2010month mortality (42.1% vs. 30.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.095 [log\u2010rank test]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Large hemispheric infarction patients over 60\u00a0years old were a little more than those aged \u226460\u00a0years and constitute more than half of those suffered from malignant brain edema and two thirds of in\u2010hospital death and 3\u2010month mortality. The elderly had more cardio\u2010origin risk factors, received less aggressive hospital treatment, and showed higher risk of unfavorable outcome than the younger.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1158","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T08:58:28Z","timestamp":1545209908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Age\u2010specific clinical characteristics and outcome in patients over 60\u00a0years old with large hemispheric infarction"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-4232","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology People\u2019s Hospital of Deyang City Deyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology People\u2019s Hospital of Deyang City Deyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendan","family":"Tao","sequence":"additional","affiliation":[{"name":"Stroke Clinical Research Unit, Department of Neurology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurology People\u2019s Hospital of Deyang City Deyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology People\u2019s Hospital of Deyang City Deyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.3.FOCUS0958"},{"issue":"1","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0034-8376(25)00223-2","article-title":"Malignant middle cerebral artery infarction: A clinical study of 32 patients","volume":"67","author":"Arboix A.","year":"2015","journal-title":"Revista De Investigaci\u00f3n Cl\u00ednica"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050625"},{"issue":"7","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1212\/WNL.52.7.1374","article-title":"Survival and outcome after endotracheal intubation for acute stroke","volume":"52","author":"Bushnell C. 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