{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:29:49Z","timestamp":1776731389586,"version":"3.51.2"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005636","name":"National Operating Committee on Standards for Athletic Equipment","doi-asserted-by":"publisher","award":["22\u201012"],"award-info":[{"award-number":["22\u201012"]}],"id":[{"id":"10.13039\/100005636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We compared the integrity of white matter (WM) microstructure to the course of recovery in athletes who sustained one sports\u2010related concussion (SRC), assessing individual longitudinal changes in WM fiber tracts following SRC using pre\u2010 and post\u2010injury measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Baseline diffusion tensor imaging (DTI) scans and neuropsychological tests were collected on 53 varsity contact\u2010sport college athletes. Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) who subsequently sustained an SRC underwent DTI scans and neuropsychological testing at 2\u00a0days, 2\u00a0weeks, and 2\u00a0months following injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relying on tract\u2010based spatial statistics (TBSS) analyses, we found that radial diffusivity (RD) and mean diffusivity (MD) were significantly increased at 2\u00a0days post\u2010injury compared to the same\u2010subject baseline (corrected <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.02). These alterations were visible in anterior\/posterior WM regions spanning both hemispheres, demonstrating a diffuse pattern of injury after concussion. Implicated WM fiber tracts at 2\u00a0days include the following: right superior\/inferior longitudinal fasciculus; right\/left inferior fronto\u2010occipital fasciculus; right corticospinal tract; right acoustic radiation; right\/left anterior thalamic radiations; right\/left uncinate fasciculus; and forceps major\/minor. At 2\u00a0weeks post\u2010injury, persistently elevated RD and MD were observed solely in prefrontal portions of WM fiber tracts (using same\u2010subject contrasts). No significant differences were found for FA in any of the post\u2010injury comparisons to baseline. Plots of individual subject RD and MD in prefrontal WM demonstrated homogenous increases from baseline to just after SRC; thereafter, trajectories became more variable. Most subjects\u2019 diffusivity values remained elevated at 2\u00a0months post\u2010injury relative to their own baseline. Over the 2\u2010month period after SRC, recovery of WM fiber tracts appeared to follow a posterior\u2010to\u2010anterior trend, paralleling the posterior\u2013anterior pattern of WM maturation previously identified in the normal population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest greater vulnerability of prefrontal regions to SRC, underline the importance of an individualized approach to concussion management, and show promise for using RD and MD for imaging\u2010based diagnosis of SRC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1165","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T15:18:49Z","timestamp":1545232729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Preliminary evidence from a prospective DTI study suggests a posterior\u2010to\u2010anterior pattern of recovery in college athletes with 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