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Many patients with NDfE experience cognitive impairments, particularly with respect to memory, sustained attention, mental flexibility, and executive functioning. Cognitive impairments have been related to alterations in resting\u2010state functional brain networks in patients with neurological disorders. In the present study, we investigated whether patients with NDfE had altered connectivity in large\u2010scale functional networks using resting\u2010state functional MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 27 adults with NDfE and 36 age\u2010 and sex\u2010matched healthy controls. Resting\u2010state functional MRI was analyzed using the Functional Connectivity Toolbox (CONN). We investigate reproducibly determined large\u2010scale functional networks, including the default mode, salience, fronto\u2010parietal attention, sensorimotor, and language networks using a seed\u2010based approach. Network comparisons between patients and controls were thresholded using a FDR cluster\u2010level correction approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no significant differences in functional connectivity between seeds within the default mode, salience, sensorimotor, and language networks and other regions of the brain between patients and controls. However, patients with NDfE had significantly reduced connectivity between intraparietal seeds within the fronto\u2010parietal attention network and predominantly frontal and temporal cortical regions relative to controls; this finding was demonstrated including and excluding the patients with brain lesions. No common alteration in brain structure was observed in patients using voxel\u2010based morphometry. Findings were not influenced by treatment outcome at 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with focal epilepsy have brain functional connectivity alterations at diagnosis. Functional brain abnormalities are not necessarily a consequence of the chronicity of epilepsy and are present when seizures first emerge.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1168","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T06:50:12Z","timestamp":1543474212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Resting\u2010state functional brain networks in adults with a new diagnosis of focal epilepsy"],"prefix":"10.1002","volume":"9","author":[{"given":"Batil K.","family":"Alonazi","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences, Institute of Psychology, Health and Society University of Liverpool Liverpool UK"},{"name":"Department of Radiology and Medical Imaging Prince Sattam Bin Abdulaziz University Al Kharj Saudi 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