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There is evidence that ECT and MDD exert opposing effects on the hippocampal formation with respect to volume and number of neurons. However, there has been a paucity of quantitative data in experimental models of ECT and MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using design\u2010based stereology, we have measured the effects of a stress\u2010induced depression model (chronic restraint stress, CRS) and ECS on the morphology of the hippocampus by estimating the volume and total number of neurons in the hilus, CA1, and CA2\/3, as well as in the entire hippocampus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We find that CRS induces a significant decrease in volume exclusively of the hilus and that ECS (CRS\u00a0+\u00a0ECS) blocks this reduction. Furthermore, ECS alone does not change the volume or total number of neurons in the entire hippocampus or any hippocampal subdivision in our rat model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1195","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T08:34:32Z","timestamp":1547800472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Electroconvulsive treatment prevents chronic restraint stress\u2010induced atrophy of the hippocampal formation\u2014A stereological study"],"prefix":"10.1002","volume":"9","author":[{"given":"Johanne L.","family":"Alemu","sequence":"first","affiliation":[{"name":"Research Laboratory for Stereology and Neuroscience Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Elberling","sequence":"additional","affiliation":[{"name":"Research Laboratory for Stereology 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