{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:51:23Z","timestamp":1790646683196,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21-MH099388"],"award-info":[{"award-number":["R21-MH099388"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obsessional thoughts and ritualized eating behaviors are characteristic of Anorexia Nervosa (AN), leading to the common suggestion that the illness shares neurobiology with obsessive\u2013compulsive disorder (OCD). Resting\u2010state functional connectivity MRI (rs\u2010fcMRI) is a measure of functional neural architecture. This longitudinal study examined functional connectivity in AN within the limbic cortico\u2010striato\u2010thalamo\u2010cortical (CSTC) loop, as well as in the salience network, the default mode network, and the executive control network (components of the triple network model of psychopathology).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Resting\u2010state functional connectivity MRI scans were collected in unmedicated female inpatients with AN (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a025) and healthy controls (HC;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024). Individuals with AN were scanned before and after weight restoration and followed for one month after hospital discharge. HC were scanned twice over the same timeframe.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Using a seed\u2010based correlation approach, individuals with AN had increased connectivity within the limbic CSTC loop when underweight, only. There was no significant association between limbic CSTC connectivity and obsessive\u2013compulsive symptoms or prognosis. Exploratory analyses of functional network connectivity within the triple network model showed reduced connectivity between the salience network and left executive control network among AN relative to HC. These abnormalities persisted following weight restoration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CSTC findings suggest that the neural underpinnings of obsessive\u2013compulsive symptoms may differ from those of OCD. The inter\u2010network abnormalities warrant examination in relation to illness\u2010specific behaviors, namely abnormal eating behavior. This longitudinal study highlights the complexity of the neural underpinnings of AN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1205","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T19:56:32Z","timestamp":1545940592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Resting\u2010state connectivity within and across neural circuits in anorexia nervosa"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-3575","authenticated-orcid":false,"given":"Blair","family":"Uniacke","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center New York New York"},{"name":"Department of Psychiatry New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center New York New York"},{"name":"Department of Psychiatry New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Biezonski","sequence":"additional","affiliation":[{"name":"Rockefeller University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Sussman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center New York New York"},{"name":"Department of Psychiatry New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonjoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Mental Health Data Science New York State Psychiatric Institute New York New York"},{"name":"Department of Biostatistics Columbia University Irving Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Posner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center New York New York"},{"name":"Department of Psychiatry New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Steinglass","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University Irving Medical Center New York New York"},{"name":"Department of Psychiatry New York State Psychiatric Institute New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.DSM\u20105 task force. 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