{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:34:07Z","timestamp":1775064847327,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["No 14.621.21.0014"],"award-info":[{"award-number":["No 14.621.21.0014"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The applicability of \u201cRubidium Chloride, <jats:sup>82<\/jats:sup>Rb from Generator\u201d radiopharmaceutical for brain tumors (BT) diagnostics is demonstrated on the basis of the application experience of the radiopharmaceutical in neurooncology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental<\/jats:title><jats:p>A total of 21 patients with various brain tumors and nonneoplastic abnormal brain masses were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Discussions<\/jats:title><jats:p>The results of the imaging and differential diagnostics of malignant and benign tumors, nonneoplastic abnormal brain masses and lesions revealed the prevalence of high uptake of the radiopharmaceutical in the malignant tumors in comparison with benign glioma and arteriovenous malformations in which <jats:sup>82<\/jats:sup>Rb\u2010chloride accumulates in the vascular phase but does not linger further. The ultra\u2010short half\u2010life of radionuclide <jats:sup>82<\/jats:sup>Rb (76\u00a0s) along with a low absorbed radiation dose with <jats:sup>82<\/jats:sup>Rb\u2010chloride by intravenous administration create a new possibility of successive use of two or more radiopharmaceuticals for the examination of the same patient. For instance, PET examination with <jats:sup>18<\/jats:sup>F\u2010FDG, <jats:sup>11<\/jats:sup>C\u2010methionine, <jats:sup>11<\/jats:sup>C\u2010choline, or any other radiopharmaceutical can be carried out in just 7\u201315\u00a0min. after <jats:sup>82<\/jats:sup>Rb\u2010chloride injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Research demonstrated an effectiveness of <jats:sup>82<\/jats:sup>Rb\u2010chloride application as a diagnostic agent in neurooncology. A method of dosing and administration of the generator\u2010produced radiopharmaceutical has been worked out. It is possible to do up to 600 PET sessions using one Russian <jats:sup>82<\/jats:sup>Rb generator GR\u201001. The generator is proved to be reliable and easy to use. The interest in <jats:sup>82<\/jats:sup>Rb\u2010chloride as a tumor\u2010seeking radiopharmaceutical rose due to the active application of the modern devices PET\/CT in the routine clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1212","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T05:11:18Z","timestamp":1549516278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Application of <sup>82<\/sup>Sr\/<sup>82<\/sup>Rb generator in neurooncology"],"prefix":"10.1002","volume":"9","author":[{"given":"Nikolay A.","family":"Kostenikov","sequence":"first","affiliation":[{"name":"Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public Health  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-052X","authenticated-orcid":false,"given":"Boris L.","family":"Zhuikov","sequence":"additional","affiliation":[{"name":"Institute for Nuclear Research of Russian Academy of Sciences (INR RAS)  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriy M.","family":"Chudakov","sequence":"additional","affiliation":[{"name":"Institute for Nuclear Research of Russian Academy of Sciences (INR RAS)  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy R.","family":"Iliuschenko","sequence":"additional","affiliation":[{"name":"Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public Health  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V.","family":"Shatik","sequence":"additional","affiliation":[{"name":"Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public Health  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim V.","family":"Zaitsev","sequence":"additional","affiliation":[{"name":"Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public Health  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitriy S.","family":"Sysoev","sequence":"additional","affiliation":[{"name":"Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public Health  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey A.","family":"Stanzhevskiy","sequence":"additional","affiliation":[{"name":"Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public Health  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2015.06.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"Beyer G. 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