{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:18:24Z","timestamp":1790842704522,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major project of Tianjin science and technology, prevention and control technology of chronic disease","award":["17ZXMFSY00180"],"award-info":[{"award-number":["17ZXMFSY00180"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the sleep characteristics and cognition between rapid eye movement sleep behavior disorder (RBD) patients and non\u2010RBD (nRBD) healthy control subjects and to determine the correlation between sleep and cognition in RBD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Polysomnography (PSG) was performed to confirm and exclude RBD. Fifteen iRBD patients, 12 PD with RBD patients, and 23 matched nRBD healthy control subjects were enrolled. Subjective sleep and neuropsychological evaluations were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were found in the subjective sleep among the three groups. Compared to the nRBD subjects, iRBD patients showed higher PLMI, the PD with RBD patients showed an increased proportion of N1 sleep, a decreased proportion of N2 and N3 sleep, and an increased periodic leg movement index. The iRBD patients performed worse on RCFT time than the nRBD subjects, the PD with RBD patients performed worse than the nRBD subjects on the following evaluations: the Mini\u2010Mental State Examination; auditory verbal learning test (AVLT); Rey Complex Figure Test (RCFT) time, Clock drawing test (CDT); delay memory score of RCFT; Symbol digit modalities test (SDMT); Trail Making Test (TMT); and Stroop Test B and C, all significant changes (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Furthermore, in RBD patients, lower sleep efficiency was correlated with decreased SDMT scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.694, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), longer time on the TMT A (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.589, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), and lower city fluency test scores(<jats:italic>r<\/jats:italic>\u00a0=\u00a00.556, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Less total sleep time was correlated with lower RCFT scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.392, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043), longer time on the TMT A (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.417, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.031), and lower city fluency test scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.405, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PD with RBD patients suffered from abnormal sleep architecture and extensive cognition dysfunction. Decreased total sleep time and sleep efficiency may contribute to cognitive deterioration in RBD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1220","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T05:10:24Z","timestamp":1550207424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Polysomnographic and neuropsychological characteristics of rapid eye movement sleep behavior disorder patients"],"prefix":"10.1002","volume":"9","author":[{"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Airport Site Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Imaging Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3300-736X","authenticated-orcid":false,"given":"Jingyi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Imaging Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin People\u2019s Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-8212","authenticated-orcid":false,"given":"Rong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100720200003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545813"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704101069"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/23.4.1e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01484.x"},{"issue":"5","key":"e_1_2_8_7_1","first-page":"619","article-title":"Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder","volume":"34","author":"Fantini M. L.","year":"2011","journal-title":"Sleep"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000101726.69701.FA"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21680"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181999e92"},{"key":"e_1_2_8_11_1","article-title":"Prevalence and determinants of REM sleep behavior disorder in the general population","author":"Haba\u2010Rubio J.","year":"2017","journal-title":"Sleep"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(93)90111-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.157"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089741"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70056-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9831-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.11.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.035"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000286943.79593.a6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.02.003"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2013_251"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.03.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.04.003"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03034.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25820"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005523"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2626(92)90112-Y"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3224"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0970"},{"issue":"8","key":"e_1_2_8_31_1","first-page":"1066","article-title":"Increased percentage of slow\u2010wave sleep in REM sleep behavior disorder (RBD): A reanalysis of previously published data from a controlled study of RBD reported in SLEEP","volume":"26","author":"Schenck C. H.","year":"2003","journal-title":"Sleep"},{"key":"e_1_2_8_32_1","volume-title":"A compendium of neuropsychological tests: Administration, norms, and commentary","author":"Strauss E.","year":"2006"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx058"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.06.013"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3050"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2592-15.2015"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25034"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249098"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-311437"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.176077"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.12.020"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.1220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T05:30:55Z","timestamp":1694410255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,14]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/brb3.1220"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1220","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,14]]},"assertion":[{"value":"2018-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01220"}}