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Here, we compared the presence of CoW variants in patients with stroke with and without migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness\/hypoplasia (any segment\u00a0&lt;1\u00a0mm), for anterior cerebral artery asymmetry (difference\u00a0&gt;\u00a01\/3), and for posterior communicating artery (Pcom) dominance (Pcom\u2013P1 difference\u00a0&gt;\u00a01\/3). Odds ratios with adjustments for age and sex (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) were calculated with logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.47; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.63\u20133.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 0.86; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.43\u20131.74), or Pcom dominance (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 0.64; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.32\u20131.30). There were no differences in CoW variations between migraine patients with or without aura.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1223","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T05:09:20Z","timestamp":1550380160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Circle of Willis variations in migraine patients with ischemic stroke"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-3610","authenticated-orcid":false,"given":"Arend M.","family":"Hamming","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne A. 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Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta K.","family":"Velthuis","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel D.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela M.","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke C.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Neurology VU Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"Schonewille","sequence":"additional","affiliation":[{"name":"Department of Neurology Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center Leiden The Netherlands"},{"name":"The Julius Center University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke J. 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