{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:36:43Z","timestamp":1757313403829},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,17]],"date-time":"2013-02-17T00:00:00Z","timestamp":1361059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"State of S\u00e3o Paulo Research Foundation (FAPESP)"},{"name":"National Council for Scientific and Technological Development (CNPq)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pineal gland and its hormone melatonin have been implicated in modulation of cardiovascular system. We aimed at studying the effects of melatonin on baroreflex sensitivity and the role of area postrema, as a component modulator of baroreflex arch. Mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) and heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) were recorded in conscious freely moving rats. Baroreceptor reflex sensitivity was assessed by determining the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> responses to ramped infusions of phenylephrine (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) and sodium nitroprusside (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>)\u2010induced <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> changes. Melatonin bolus (0.11\u00a0mg\/kg) immediately followed by its continuous infusion (0.43\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>\u00a0mol\/L at a rate of 0.65\u00a0mL\/h for 30\u00a0min) in healthy normotensive rats produced a downward shift of baroreceptor reflex control with a substantial inhibition of reflex tachycardia (\u221232%) and potentiation of reflex bradycardia (+20%). Ablation of area postrema (<jats:styled-content style=\"fixed-case\">APX<\/jats:styled-content> group) induced a sustained decrease of <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> (101\u00a0\u00b1\u00a03 vs. 116\u00a0\u00b1\u00a03\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 in comparison with sham rats, respectively). The melatonin\u2010induced alterations of baroreflex function observed in the sham group were abolished in the <jats:styled-content style=\"fixed-case\">APX<\/jats:styled-content> group. We conclude that circulating melatonin can modulate baroreceptor reflex control of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, thus resetting it toward lower <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> values. The modulatory effects of melatonin may be mediated via melatonin receptors in the area postrema, located outside the blood\u2013brain barrier.<\/jats:p>","DOI":"10.1002\/brb3.123","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T21:31:36Z","timestamp":1361223096000},"page":"171-177","source":"Crossref","is-referenced-by-count":13,"title":["Melatonin modulates baroreflex control via area postrema"],"prefix":"10.1002","volume":"3","author":[{"given":"Luciana A.","family":"Campos","sequence":"first","affiliation":[{"name":"S\u00e3o Jos\u00e9 dos Campos Technology Park University Camilo Castelo Branco (UNICASTELO) S\u00e3o Paulo Brazil"},{"name":"Department of Physiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Cipolla\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Physiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisete C.","family":"Michelini","sequence":"additional","affiliation":[{"name":"Department of Physiology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/107424840400900205"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1991.tb00831.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.05.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.4.R1209"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00739-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.2.323"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000049363.97713.74"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.9.4.355"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.06.009"},{"key":"e_1_2_7_11_1","first-page":"577","article-title":"Effect of melatonin on nocturnal blood pressure: meta\u2010analysis of randomized controlled trials","volume":"7","author":"Grossman E.","year":"2011","journal-title":"Vasc. 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