{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:03:23Z","timestamp":1792782203140,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Danish Research Council","award":["DFF-1317-00010"],"award-info":[{"award-number":["DFF-1317-00010"]}],"id":[{"id":"https:\/\/ror.org\/05svhj534","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We have previously shown that an interaction between medial prefrontal and parietal cortices is instrumental in promoting self\u2010awareness via synchronizing oscillations in the gamma range. The synchronization of these oscillations is modulated by dopamine release. Given that such oscillations result from intermittent GABA stimulation of pyramidal cells, it is of interest to determine whether the dopaminergic system regulates GABA release directly in cortical paralimbic regions. Here, we test the hypothesis that the regulation of the GABA\u2010ergic system by the dopaminergic system becomes attenuated in problem gamblers resulting in addictive behaviors and impaired self\u2010awareness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>11<\/jats:sup>\n                      C]Ro15\u20104513 PET, a marker of benzodiazepine\n                      <jats:italic>\u03b1<\/jats:italic>\n                      1\/\n                      <jats:italic>\u03b1<\/jats:italic>\n                      5 receptor availability in the GABA receptor complex, was used to detect changes in synaptic GABA levels after oral doses of 100mg L\u2010dopa in a double\u2010blind controlled study of male problem gamblers (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a010) and age\u2010matched healthy male controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean reduction of cortical gray matter GABA\/BDZ receptor availability induced by L\u2010dopa was significantly attenuated in the problem gambling group compared to the healthy control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0377).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that: (a) Exogenous dopamine can induce synaptic GABA release in healthy controls. (b) This release is attenuated in frontal cortical areas of males suffering from problem gambling, possibly contributing to their loss of inhibitory control. This suggests that dysfunctional dopamine regulation of GABA release may contribute to problem gambling and gambling disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1239","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T23:39:35Z","timestamp":1550705975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Attenuation of dopamine\u2010induced GABA release in problem gamblers"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-2774","authenticated-orcid":false,"given":"Arne","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Nuclear Medicine and PET\u2010Center Aarhus University Hospital Aarhus Denmark"},{"name":"Center of Functionally Integrative Neuroscience Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"R\u00f8mer 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