{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:55:42Z","timestamp":1793397342104,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,24]],"date-time":"2019-03-24T00:00:00Z","timestamp":1553385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Quality of life (QoL) after intracerebral hemorrhage (ICH) is poorly known. This study investigated factors affecting QoL and depression after spontaneous ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective study included patients admitted to Helsinki University Hospital between May 2014 and December 2016. Health\u2010related QoL (HRQoL) at 3\u00a0months after ICH was measured using the European Quality of Life Scale (EQ\u20105D\u20105L), and the 15D scale. Logistic regression analyses were used to test factors affecting HRQoL. EQ\u20105D\u20105L anxiety\/depression dimension was used to analyze factors associated with anxiety\/depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 277 patients, 220 were alive, and sent QoL questionnaire. The questionnaire was returned by 124 patients. Nonreturners had more severe strokes with admission National Institutes of Health Stroke Scale (NIHSS) 7.8 (IQR 3.0\u201314.8) versus 5.0 (IQR 2.3\u201311.0); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018, and worse outcome assessed as modified Rankin Scale 3\u20135 at 3\u00a0months 59.4% versus 44.4% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030). Predictors for lower HRQoL by both scales were higher NIHSS with OR 1.28 (95% CI 1.13\u20131.46) for EQ\u20105D\u20105L, and OR 1.28 (1.15\u20131.44) for 15D, older age (OR 1.10 [1.03\u20131.16], and OR 1.09 [1.03\u20131.15]), and chronic heart failure (OR 18.12 [1.73\u2013189.27], and OR 12.84 [1.31\u2013126.32]), respectively. Feeling sad\/depressed for more than 2\u00a0weeks during the year prior to ICH was predictor for lower EQ\u20105D\u20105L (OR 10.64 [2.39\u201347.28]), and history of ICH for lower 15D utility indexes (OR 11.85 [1.01\u2013138.90]). Prior feelings of sadness\/depression were associated with depression\/anxiety at 3\u00a0months after ICH with OR 3.62 (1.14\u201311.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort of ICH patients with milder deficits, HRQoL was affected by stroke severity, comorbidities and age. Feelings of depression before ICH had stronger influence on reporting depression\/anxiety after ICH than stroke severity\u2010related and outcome parameters. Thus, simple questions on patient's premorbid feelings of sadness\/depression could be used to identify patients at risk of depression after ICH for focusing follow\u2010up and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1270","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T06:48:37Z","timestamp":1553496517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Quality of life and depression 3 months after intracerebral hemorrhage"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-8189","authenticated-orcid":false,"given":"Hanne","family":"Sallinen","sequence":"first","affiliation":[{"name":"Department of Neurology Helsinki University Hospital and University of Helsinki Helsinki 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