{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:42:07Z","timestamp":1783770127948,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intermittent hypoxia and sleep fragmentation are critical pathophysiological processes involved in obstructive sleep apnea\u2010hypopnea syndrome (OSAHS). Those manifestations independently affect similar brain regions and contribute to OSAHS\u2010related comorbidities that are known to be related to the host gut alteration microbiota. We hypothesized that gut microbiota disruption may cross talk the brain function via the microbiota\u2013gut\u2013brain axis. Thus, we aim to survey enterotypes and polysomnographic data of patients with OSAHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were diagnosed by polysomnography, from whom fecal samples were obtained and analyzed for the microbiome composition by variable regions 3\u20134 of 16S rRNA pyrosequencing and bioinformatic analyses. We examined the fasting levels of interleukin\u20106 and tumor necrosis factor\u2010alpha of all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three enterotypes <jats:italic>Bacteroides<\/jats:italic>, <jats:italic>Ruminococcus<\/jats:italic>, and <jats:italic>Prevotella<\/jats:italic> were identified in patients with OSAHS. Arousal\u2010related parameters or sleep stages are significantly disrupted in apnea\u2010hypopnea index (AHI) \u226515 patients with <jats:italic>Prevotella<\/jats:italic> enterotype; further analysis this enterotype subjects, obstructive, central, and mixed apnea indices, and mean heart rate are also significantly elevated in AHI \u226515 patients. However, blood cytokines levels of all subjects were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study indicates the possibility of pathophysiological interplay between enterotypes and sleeps structure disruption in sleep apnea through a microbiota\u2013gut\u2013brain axis and offers some new insight toward the pathogenesis of OSAHS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1287","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T09:20:20Z","timestamp":1554715220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Disruption of sleep architecture in <i>Prevotella<\/i> enterotype of patients with obstructive sleep apnea\u2010hypopnea syndrome"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-3041","authenticated-orcid":false,"given":"Chih\u2010Yuan","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine the Second Affiliated Hospital of Fujian Medical University Quanzhou China"},{"name":"Respiratory Medicine Center of Fujian Province Quanzhou China"},{"name":"Key Laboratory of Fujian Medical University, Fujian Province University Quanzhou China"},{"name":"Department of Endocrinology and Metabolism the Second Affiliated Hospital of Fujian Medical University Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Mim","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine the Second Affiliated Hospital of Fujian Medical University Quanzhou China"},{"name":"Respiratory Medicine Center of Fujian Province Quanzhou China"},{"name":"Key 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