{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:02Z","timestamp":1753862702564,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lowering homocysteine (<jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content>) has beneficial effects on vascular events in primary prevention but not in secondary prevention. Research on serum <jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content> level and middle cerebral artery (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>) stenosis is lacking. The purpose of the study was to determine the association between these factors and provide more evidence for the prevention of ischemic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 412 patients (35\u201393\u00a0years old) in the Neurology Department were recruited. Data of clinical and biochemical vascular risk factors were collected. <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> stenosis, including M1, M2, and M3, was determined by brain magnetic resonance angiography (<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>) and classified into stenosis or no stenosis. The differences and associations were analyzed by relevant statistical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.325) in <jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content> levels between the <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> stenosis and no stenosis groups at baseline. Logistic regression analysis demonstrated that there was no significant association between <jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content> levels and <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> stenosis (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.447). After the two groups were matched for age and sex, there was still no difference (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.540 for males and 0.061 for females) or association (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.709 for males and 0.098 for females). In addition, we found that ischemic stroke was more prevalent in the <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> stenosis group and uric acid was higher in males with <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study indicates a lack of association between serum <jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content> level and <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> stenosis, which may partially explain the negative results of secondary prevention clinical trials focused on lowering serum <jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content> level. Future studies on <jats:styled-content style=\"fixed-case\">HCY<\/jats:styled-content> reduction should focus more on primary prevention of ischemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1297","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:08:50Z","timestamp":1561115330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lack of association between serum homocysteine level and middle cerebral artery stenosis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-6551","authenticated-orcid":false,"given":"Haitao","family":"Zhou","sequence":"first","affiliation":[{"name":"Neurology Department Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Neurology Department Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurology Department Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurology Department Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congmin","family":"Ma","sequence":"additional","affiliation":[{"name":"Neurology Department Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Ren","sequence":"additional","affiliation":[{"name":"Neurology Department Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2017.10.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.840"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.22.2720"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0423-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104253241701"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199709000-00013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00556.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.7.795"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009111"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0377-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2274"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175434"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12208"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004099"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003768"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"e_1_2_8_19_1","first-page":"111","article-title":"Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully K. 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