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MetS and its component RFs are more prevalent in older age, and can be accompanied by alterations in brain structure. Studies have shown altered functional connectivity (FC) in samples with individual RFs as well as in clinical populations that are at higher risk to develop MetS. These studies have indicated that the default mode network (DMN) may be particularly vulnerable, yet little is known about the overall impact of MetS on FC in this network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we evaluated the integrity of FC to the DMN in participants with MetS relative to non\u2010MetS individuals. Using a seed\u2010based connectivity analysis approach, resting\u2010state functional MRI (fMRI) data were analyzed, and the FC measures among the DMN seed (isthmus of the cingulate) and rest of the brain voxels were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with MetS demonstrated reduced positive connectivity between the DMN seed and left superior frontal regions, and reduced negative connectivity between the DMN seed and left superior parietal, left postcentral, right precentral, right superior temporal and right superior parietal regions, after accounting for age\u2010 and sex\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that MetS is associated with alterations in FC between the DMN and other regions of the brain. Furthermore, these results indicate that the overall burden of vascular RFs associated with MetS may, in part, contribute to the pathophysiology underlying aberrant FC in the DMN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1333","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:36:02Z","timestamp":1569908162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Aberrant patterns of default\u2010mode network functional connectivity associated with metabolic syndrome: A resting\u2010state study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-5109","authenticated-orcid":false,"given":"Barnaly","family":"Rashid","sequence":"first","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena I.","family":"Dev","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts"},{"name":"SDSU\/UCSD Joint Doctoral Program in Clinical Psychology San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-3920","authenticated-orcid":false,"given":"Michael","family":"Esterman","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Department of Psychiatry Boston University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette F.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"},{"name":"McLean Imaging Center McLean Hospital Belmont Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tori","family":"Ferland","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-1589","authenticated-orcid":false,"given":"Francesca C.","family":"Fortenbaugh","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Milberg","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina E.","family":"McGlinchey","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Salat","sequence":"additional","affiliation":[{"name":"Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC) VA Boston Healthcare System Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"},{"name":"The Athinoula A. 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