{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:23:50Z","timestamp":1761920630330,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T00:00:00Z","timestamp":1564790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671182"],"award-info":[{"award-number":["81671182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313228"],"award-info":[{"award-number":["2016A030313228"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Cl\u00ednica Universidad de Navarra\u2010Body Adiposity Estimator (CUN\u2010BAE) in NMOSD has not been investigated thus far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age\u2010 and sex\u2010matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing NMOSD patients with MS patients, the former have significantly higher SBP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), DBP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), PP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), MAP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), BF% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and BMI (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110\u201312.453) is more likely to occur in NMOSD patients with high BF% (\u226530%) at acute phase. BF% was negatively correlated with 1\/AQP4 titer in NMOSD at acute phase (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.522, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with NMOSD are probably more prone to have an increased BP and fat mass compared to MS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1350","type":"journal-article","created":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T07:38:31Z","timestamp":1564817911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blood pressure and body fat percent in women with NMOSD"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2139-3697","authenticated-orcid":false,"given":"Xiaohong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital, Sun Yat\u2010sen University Guangdong 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Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital, Sun Yat\u2010sen University Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0040-4211","authenticated-orcid":false,"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital, Sun Yat\u2010sen University Guangdong 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