{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:11:19Z","timestamp":1770700279841,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acute disseminated encephalomyelitis (ADEM) is an idiopathic inflammatory demyelinating disorder of the central nervous system (CNS). Early treatment is the key for neurological recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case of ADEM associated with varicella\u2010zoster virus infection was presented, in which magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) examinations were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Magnetic resonance imaging of the brain revealed multiple hyperintense lesions at the subcortical level on fluid\u2010attenuated inversion recovery (FLAIR), and MRI of the spinal cord revealed longitudinally segmented hyperintense lesions at the spinal cord on T2\u2010weighted images. The patient was treated with methylprednisolone and gancyclovir, and had a favorable recovery. Subsequent MRI of the brain and cervical cord showed the previous abnormal hyperintensities had markedly disappeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A rare case of ADEM with longitudinal segmented hyperintense lesions at the spinal cord on T2\u2010weighted images was presented. Excellent response to ADEM treatment with high\u2010dose steroids was reported resulting in a remarkable neurological recovery. A long\u2010term follow\u2010up is needed for prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1374","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T08:08:18Z","timestamp":1564042098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute disseminated encephalomyelitis following varicella\u2010zoster virus infection: Case report of effective treated both in clinical symptom and neuroimaging"],"prefix":"10.1002","volume":"9","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Aerospace Center Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Na","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology Aerospace Center Hospital Beijing 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