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This personality trait has been associated with psychological distress and predicts some mental disorders. Previous studies have shown that women tend to be more neurotic than men and, in general, females have also a higher incidence of anxious and depressive disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed in a sample of 99 female university students (from 18 to 26\u00a0years old) if emotional stability, measured using the Big Five Questionnaire, was linked to polymorphic variants in candidate genes related to dopaminergic and serotonergic systems, and other personality variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that emotional stability and its subdimensions are genetically associated with <jats:italic>MAOA<\/jats:italic>\u2010uVNTR polymorphism. Thus, women carriers of the 3\u2010repeat allele (lower <jats:italic>MAO\u2010A<\/jats:italic> expression) showed higher levels of emotional stability. No associations were found with other polymorphisms analyzed, including <jats:italic>COMT<\/jats:italic> Val<jats:sup>158<\/jats:sup>Met, <jats:italic>5\u2010HTTLPR<\/jats:italic>, and <jats:italic>DAT<\/jats:italic> 3\u2032UTR VNTR. Furthermore, our results showed a negative correlation between emotional stability and depression, state anxiety, and trait anxiety. In fact, <jats:italic>MAOA<\/jats:italic>\u2010uVNTR and trait anxiety also explained emotional stability and its subdimensions. We also found that other genetic characteristic, phenylthiocarbamide tasting, explained impulsivity, specifically tasters controlled impulses better than nontasters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that neuroticism might be regulated by <jats:italic>MAOA<\/jats:italic> and could be a common factor between different phenotypes, such as aggressive behaviors or personality disorders, observed in women with higher activity genotype who had been exposed to negative environments during childhood. This study could lead to a better understanding of the basis of emotional stability and could lead to future projects for this purpose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1376","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:04:21Z","timestamp":1566777861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Emotional stability is associated with the <i>MAOA<\/i> promoter uVNTR polymorphism in women"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-9783","authenticated-orcid":false,"given":"\u00c1ngel","family":"Rodr\u00edguez\u2010Ramos","sequence":"first","affiliation":[{"name":"Department of Genetics University of C\u00f3rdoba C\u00f3rdoba Spain"},{"name":"Department of Psychology University of C\u00f3rdoba C\u00f3rdoba Spain"},{"name":"Maim\u00f3nides Biomedical Research Institute of C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"},{"name":"University Hospital Reina Sof\u00eda of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-821X","authenticated-orcid":false,"given":"Juan Antonio","family":"Moriana","sequence":"additional","affiliation":[{"name":"Department of Psychology University of C\u00f3rdoba C\u00f3rdoba Spain"},{"name":"Maim\u00f3nides Biomedical Research Institute of C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"},{"name":"University Hospital Reina Sof\u00eda of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5129-6951","authenticated-orcid":false,"given":"Francisco","family":"Garc\u00eda\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Psychology University of C\u00f3rdoba C\u00f3rdoba Spain"},{"name":"Maim\u00f3nides Biomedical Research Institute of C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"},{"name":"University Hospital Reina Sof\u00eda of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-4377","authenticated-orcid":false,"given":"Manuel","family":"Ruiz\u2010Rubio","sequence":"additional","affiliation":[{"name":"Department of Genetics University of C\u00f3rdoba C\u00f3rdoba Spain"},{"name":"Maim\u00f3nides Biomedical Research Institute of C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"},{"name":"University Hospital Reina Sof\u00eda of C\u00f3rdoba C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0047.2004.00325.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2011.01764.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-010-9356-y"},{"key":"e_1_2_8_5_1","volume-title":"Manual for the beck depression inventory\u2013II","author":"Beck A. 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