{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:12:00Z","timestamp":1787065920357,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701161"],"award-info":[{"award-number":["81701161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YR201802"],"award-info":[{"award-number":["YR201802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KY24520346"],"award-info":[{"award-number":["KY24520346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KGF2019G02"],"award-info":[{"award-number":["KGF2019G02"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The neutrophil\u2010to\u2010lymphocyte ratio (NLR) has been shown to be a marker associated with inflammation and is independently associated with the adverse clinical outcomes of symptomatic intracranial hemorrhage, cancer, and cardiovascular disease. Hemorrhagic transformation (HT) is a serious complication of ischemic cerebral infarction and can be intensified by therapeutic interventions for acute ischemic stroke (AIS). The purpose of our research was to explore the predictive effect of NLR for HT in patients with AIS and to determine the best predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, EMBASE, MEDLINE, Cochrane, and Google Scholar were searched. The primary endpoint was HT, and subgroup analysis was performed. Review Manager software version 5.3 was used to statistically analyze the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of seven studies including 3,726 patients met the inclusion criteria. The pooled odds ratio (OR) value of the high NLR that predicted HT in AIS patients was 1.53 (95% CI, 1.21\u20131.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0003). In addition, 1.10 (95% CI, 1.05\u20131.15;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) was the pooled OR of the high NLR associated with increased 3\u2010month mortality in patients with AIS. In the subgroup analysis with an NLR cutoff value of 7.5\u201311, the correlation between NLR above the cutoff value and the rate of HT in patients with AIS was statistically significant (OR, 7.93; 95% CI, 2.25\u201327.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A high NLR can predict HT and 3\u2010month mortality in patients with AIS. Regardless of the country of origin and the sampling time, an NLR with a cutoff value of 7.5\u201311 was independently associated with HT in AIS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1382","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T06:09:14Z","timestamp":1566281354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Neutrophil\u2010to\u2010lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: A meta\u2010analysis"],"prefix":"10.1002","volume":"9","author":[{"given":"Ruirui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoucai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-3885","authenticated-orcid":false,"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Wannan Medical College First Affiliated Hospital Yijishan Hospital Wuhu China"},{"name":"Key Laboratory of Non\u2010coding RNA Transformation Research of Anhui Higher Education Institutes Wannan Medical College Wuhu China"},{"name":"Non\u2010coding RNA Research Center of Wannan Medical College Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.115792"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/erc.12.159"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010780"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489401"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2017.03.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.08.028"},{"issue":"5","key":"e_1_2_9_8_1","first-page":"653","article-title":"Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack","volume":"17","author":"Gokhan S.","year":"2013","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3181fcb238"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021477"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0680-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016368"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.04.015"},{"key":"e_1_2_9_14_1","first-page":"367","article-title":"The effects of neutrophil to lymphocyte and platelet to lymphocyte ratios on prognosis in patients undergoing mechanical thrombectomy for acute ischemic stroke","volume":"89","author":"Inanc Y.","year":"2018","journal-title":"Annali Italiani di Chirurgia"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.203"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.02.042"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000092527.33910.89"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0649-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01683.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.114"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002029"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13741"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.12.044"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00878-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.01.021"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1359-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9707-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.500868"},{"key":"e_1_2_9_29_1","article-title":"Increased neutrophil\u2010to\u2010lymphocyte ratios are associated with greater risk of hemorrhagic transformation in patients with acute ischemic stroke","author":"Song Q.","year":"2018","journal-title":"Current Neurovascular Research"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223883"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.04.007"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010049"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.11.010"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20120"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.02.002"},{"issue":"1","key":"e_1_2_9_36_1","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R.","year":"2001","journal-title":"Bratislavske Lekarske Listy"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008624"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T06:53:34Z","timestamp":1694156014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/brb3.1382"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1382","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"2019-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01382"}}