{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:20:27Z","timestamp":1792102827374,"version":"4.4.0"},"reference-count":156,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sexual desire, arousal, and orgasm are mediated by complex, yet still not fully understood, interactions of the somatic and autonomic nervous systems operating at the central and peripheral levels. Disruption of endocrine, neural, or vascular response, caused by aging, medical illness, neurological diseases, surgery, or drugs, can lead to sexual dysfunctions, thus significantly affecting patients' quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This narrative review aims at characterizing the involvement of the central nervous system in human sexual behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted using PubMed in its entirety up to June 2018, analyzing the studies dealing with the neurobiological and neurophysiological basis of human sexuality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sexual behavior is regulated by both subcortical structures, such as the hypothalamus, brainstem, and spinal cord, and several cortical brain areas acting as an orchestra to finely adjust this primitive, complex, and versatile behavior. At the central level, dopaminergic and serotonergic systems appear to play a significant role in various factors of sexual response, although adrenergic, cholinergic, and other neuropeptide transmitter systems may contribute as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Providing healthcare professionals with information concerning sexual behavior may overcome useless and sometimes dangerous barriers and improve patient management, since sexual well\u2010being is considered one of the most important aspects of one's quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1389","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:30:15Z","timestamp":1569907815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":180,"title":["Neuroanatomy and function of human sexual behavior: A neglected or unknown issue?"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-3166","authenticated-orcid":false,"given":"Rocco S.","family":"Calabr\u00f2","sequence":"first","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino Pulejo\u201d Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cacciola","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino Pulejo\u201d Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Bruschetta","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Dental Sciences and Morphological and Functional Images University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrio","family":"Milardi","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino Pulejo\u201d Messina Italy"},{"name":"Department of Biomedical, Dental Sciences and Morphological and Functional Images University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Quattrini","sequence":"additional","affiliation":[{"name":"University of Chieti Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sciarrone","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino Pulejo\u201d Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"la Rosa","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino Pulejo\u201d Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi \u201cBonino Pulejo\u201d Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Anastasi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Dental Sciences and Morphological and Functional Images University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901558"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/30982"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/372669a0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1884"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.10.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.01.050"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)80003-Q"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf108"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10997"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.107193"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.10.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0118"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00224490209552114"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)02961-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.018"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475693"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042307.110802"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2009.21317"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00643.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64559-8"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.01.033"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10720160500203674"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06241.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.100.2.204"},{"key":"e_1_2_11_27_1","first-page":"1","volume-title":"Male sexual dysfunction in neurological diseases: From pathophysiology to rehabilitation","author":"Calabr\u00f2 R. S.","year":"2011"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2013.865183"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2011.600647"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.11.038"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.11.58"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199541164.001.0001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3402\/snp.v5.26428"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001506"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1300\/J056v02n01_04"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.951324"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2017.10.068"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-79-4-783"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.05.030"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2014.10.007"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4176-05.2006"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2005.08.006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5664-09.2010"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291705005891"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.025"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1103"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(96)00054-7"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22528"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.05.004"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.151"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.05.055"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.12.009"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.12.023"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12926"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1300\/J088v06n02_05"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1201\/b10776-15"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.146"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1208"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23857"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.01.010"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.10.002"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503550112"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245929"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.057"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.08.018"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/00224490009552016"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.01.029"},{"key":"e_1_2_11_68_1","first-page":"396","article-title":"Different effects of cocaine and nomifensine on dopamine uptake in the caudate\u2010putamen and nucleus accumbens","volume":"274","author":"Jones S. R.","year":"1995","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_11_69_1","volume-title":"The new sex therapy. Active treatment of sexual dysfunctions","author":"Kaplan H. S.","year":"1974"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03429.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000131"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.01.013"},{"key":"e_1_2_11_73_1","first-page":"62","article-title":"Functional MRI of the brain during orgasm in women","volume":"16","author":"Komisaruk B. R.","year":"2005","journal-title":"Annual Review of Sex Research"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0019635"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1770057"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(01)00036-7"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2016.04.002"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475721"},{"issue":"5","key":"e_1_2_11_79_1","first-page":"20703","article-title":"Inhibitory inputs from rostromedial tegmental neurons regulate spontaneous activity of midbrain dopamine cells and their responses to drugs of abuse","volume":"37","author":"Lecca S.","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/00224499009551552"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.11.041"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1887219"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/14681990310001609859"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:23:2-3:101"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6163211"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90292-5"},{"key":"e_1_2_11_87_1","volume-title":"Human sexual response","author":"Masters W. H.","year":"1966"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.014"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23809"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900484"},{"key":"e_1_2_11_91_1","first-page":"138","article-title":"Approach\u2010avoidance conflict","volume":"1","author":"McNaughton N.","year":"2010","journal-title":"The Corsini Encyclopedia of Psychology"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.11.1012"},{"key":"e_1_2_11_93_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oso\/9780195134759.001.0001","volume-title":"Principles of behavioral and cognitive neurology","author":"Mesulam M.\u2010M.","year":"2000"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.167"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000198"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3109\/13685530903294388"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.10111.x"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08610.x"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2004.00514.x"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2006000100032"},{"issue":"3","key":"e_1_2_11_101_1","first-page":"97","article-title":"Role of testosterone in feminine sexuality","volume":"26","author":"Nappi R. E.","year":"2003","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.19"},{"key":"e_1_2_11_103_1","first-page":"131","article-title":"The Franck Drawing Completion Test as a tool for assessing the structure of deep sexual identity in Italian people","volume":"11","author":"Olivetti Belardinelli M.","year":"1994","journal-title":"Science Contribution General Psychology"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/940613"},{"key":"e_1_2_11_105_1","first-page":"68","article-title":"Role of the medial preoptic area\/anterior hypothalamus in the control of masculine sexual behavior","volume":"8","author":"Paredes R. G.","year":"1997","journal-title":"Annual Review of Sex Research"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00914-7"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)00992-X"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900649"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017504"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2001.10400569"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01309.x"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(87)80002-7"},{"issue":"1","key":"e_1_2_11_113_1","first-page":"1","article-title":"What can animal models tell us about human sexual response?","volume":"14","author":"Pfaus J. G.","year":"2003","journal-title":"Annual Review of Sex Research"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.04.015"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.06.025"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903180102"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(99)00020-7"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(01)00215-X"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200011)11:3<162::AID-HBM30>3.0.CO;2-A"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2004.09.016"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00480020070007"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-007-9217-9"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(94)00063-7"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.121.2.237"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18372-0"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41314"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2015.10.004"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.10.007"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsv157"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314190110"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23447"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2007.04.006"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-6-24"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23859"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40101-016-0089-3"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463712438299"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.43634"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1932"},{"key":"e_1_2_11_139_1","article-title":"Clinical case report: Hypersexuality and dysexecutive syndrome after a thalamic infarct, 114","volume":"1581","author":"Spinella M.","year":"2004","journal-title":"International Journal of Neuroscience"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00019-1"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.03.006"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01265-X"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901098"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3857"},{"key":"e_1_2_11_145_1","article-title":"Regulation of masculine sexual behavior: Involvement of brain opioids and dopamine","author":"Furth W. R.","year":"1995","journal-title":"Brain Research Reviews"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4901-04.2006"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-013-9252-1"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102419"},{"key":"e_1_2_11_149_1","first-page":"2865","article-title":"From affect to control: Functional specialization of the insula in motivation and regulation","volume":"129","author":"Wager T. D.","year":"2004","journal-title":"Emotion"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12096"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.3402\/snp.v6.31481"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.036"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(96)84721-7"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000128704.51870.87"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.06.020"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22925"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00337.2007"}],"container-title":["Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbrb3.1389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/brb3.1389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/brb3.1389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T09:07:36Z","timestamp":1721812056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/brb3.1389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":156,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/brb3.1389"],"URL":"https:\/\/doi.org\/10.1002\/brb3.1389","archive":["Portico"],"relation":{},"ISSN":["2162-3279","2162-3279"],"issn-type":[{"value":"2162-3279","type":"print"},{"value":"2162-3279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01389"}}