{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:27:30Z","timestamp":1791638850009,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T00:00:00Z","timestamp":1569024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although recent studies have shown that botulinum toxin\u2010A (BTX\u2010A) has a good analgesic effect on trigeminal neuralgia (TN) and peripheral neuropathic pain (PNP), the quality of evidence is low due to limited data. This meta\u2010analysis is used to synthesize existing evidence for the treatment of these conditions with BTX\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant trials were accessed by using an electronic search in databases (Web of Science, PubMed, EMBASE, Cochrane Library, and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>). Data from included randomized controlled trials (RCTs) on the efficacy and safety of BTX\u2010A in treating TN and PNP were extracted for meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, 10 RCTs (<jats:italic>n<\/jats:italic>\u00a0=\u00a0391) were included in this meta\u2010analysis. The pooled effect of BTX\u2010A was superior to placebo based on pain intensity (SMD\u00a0=\u00a0\u22120.48, 95% CI [\u22120.74, 0.23] at 1\u00a0month, SMD\u00a0=\u00a0\u22120.58, 95% CI [\u22120.91, \u22120.24] at 2\u00a0months, and SMD\u00a0=\u00a0\u22120.55, 95% CI [\u22120.87, \u22120.22] at 3\u00a0months). Number needed to treat (NNT) for 50% pain intensity reduction showed better effect of BTX\u2010A on TN and postherpetic neuralgia (PN). Adverse events associated with BTX\u2010A were similar to placebo (OR\u00a0=\u00a01.58, 95% CI [0.51, 4.87], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.424).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pooled data from our meta\u2010analysis suggest that BTX\u2010A is efficacious and safe in treating TN and PNP. However, due to the limited sample size and heterogeneity, further larger and well\u2010designed RCTs are imperative to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1409","type":"journal-article","created":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T08:18:03Z","timestamp":1569053883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The efficacy and safety of botulinum toxin type A in treatment of trigeminal neuralgia and peripheral neuropathic pain: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"9","author":[{"given":"Jiangshan","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology Hongze Huai'an District People's Hospital Huai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"ICU The Second People's Hospital of Huai'an 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