{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:32:12Z","timestamp":1778283132979,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR\u20102016\u201002361783"],"award-info":[{"award-number":["GR\u20102016\u201002361783"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC09\u201010\u201011\u201012\u201013\u201014\/A"],"award-info":[{"award-number":["RC09\u201010\u201011\u201012\u201013\u201014\/A"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Phenotypic variants of progressive supranuclear palsy (PSP) are all characterized by the combination of motor symptoms of parkinsonism with a number of neuropsychiatric and cognitive disorders. Despite the strong effort in characterizing these features in PSP, alexithymia and anhedonia have not been investigated at present. Here, we aimed at investigating the qualitative and quantitative differences of alexithymia and anhedonia in the two more frequent variants of PSP, Richardson's syndrome (PSP\u2010RS) and PSP with predominant parkinsonism (PSP\u2010P) compared to Parkinson's disease (PD) patients recruited within 24\u00a0months after the onset of motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred fifty\u2010five PD, 11 PSP\u2010P, and 14 PSP\u2010RS patients underwent clinical, neuropsychiatric, and neuropsychological evaluations. Alexithymia was assessed using the Toronto Alexithymia Scale\u201020 item (TAS\u201020), and hedonic tone was measured by the Snaith\u2013Hamilton Pleasure Scale (SHAPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In PSP\u2010P and PSP\u2010RS patients, the frequency of alexithymia diagnosis was higher than in PD. On the TAS\u201020 scores, PSP\u2010RS performed worse in the total score and in F2 sub\u2010scale when compared to PD. Among patients with diagnosis of depression, PSP\u2010RS showed higher scores in TAS\u201020 total and TAS\u201020 F2 than PD. No significant differences in TAS\u201020 scores were found in nondepressed patients. Finally, we did not find significant differences among PD, PSP\u2010P, and PSP\u2010RS\u00a0groups in the SHAPS scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alexithymia is identifiable very early in PSP\u2010P and PSP\u2010RS patients. Alexithymic symptoms differentiate PSP\u2010RS group from PD group but not between the two subtypes of PSP. Further, alexithymia in PSP seems to be predicted by the presence of depression. Altered emotional capability could be related to specific neurophysiological dysfunction occurring precociously in PSP; therefore, its identification could orient the diagnosis toward PSP cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1448","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T19:24:17Z","timestamp":1574191457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Alexithymia and anhedonia in early Richardson's syndrome and progressive supranuclear palsy with predominant parkinsonism"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-7879","authenticated-orcid":false,"given":"Francesca","family":"Assogna","sequence":"first","affiliation":[{"name":"Fondazione Santa Lucia IRCCS Roma 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