{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:35:02Z","timestamp":1775165702307,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EB0160100"],"award-info":[{"award-number":["EB0160100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cocaine dependence affects millions of individuals worldwide; however, there are no pharmacotherapeutic and\/or diagnostic solutions. Recent evidence suggests a role for lipid signaling in the development and maintenance of addiction, highlighting the need to understand how lipid remodeling mediates neuroadaptation after cocaine exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized shotgun lipidomics to assess cocaine\u2010induced lipid remodeling in rats using a novel behavioral regimen that incorporated multiple sessions of extinction training and reinstatement testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mass spectrometric imaging demonstrated widespread decreases in phospholipid (PL) abundance throughout the brain, and high\u2010spatial resolution matrix\u2010assisted laser desorption\/ionization Fourier\u2010transform ion cyclotron resonance mass spectrometry indicated hippocampus\u2010specific PL alterations following cocaine exposure. We analyzed the expression of genes involved in hippocampal lipid metabolism and observed region\u2010specific regulation. In addition, we found that cocaine exposure differentially regulates mitochondrial biogenesis in the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This work presents a comprehensive lipidomic assessment of cocaine\u2010induced lipid remodeling in the rat brain. Further, these findings indicate a potential interplay between CNS energetics and differential lipid regulation and suggest a role for cocaine in the maintenance of energy homeostasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1451","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T02:39:58Z","timestamp":1573180798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug\u2010seeking"],"prefix":"10.1002","volume":"9","author":[{"given":"Sumitra","family":"Pati","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences University of Georgia Athens GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggi","family":"Angel","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Pharmacology 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