{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:35:25Z","timestamp":1774024525665,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GINOP","award":["232-15-2016-00050"],"award-info":[{"award-number":["232-15-2016-00050"]}]},{"name":"EFOP","award":["361-16-2016-00004"],"award-info":[{"award-number":["361-16-2016-00004"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Autoantibody detection is crucial for the early diagnosis of autoimmune encephalitis (AIE) since prompt therapy can determine the disease outcome. Here, we report a single\u2010center 6\u2010year retrospective study of autoantibody testing in AIE in the Hungarian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum and\/or cerebrospinal fluid (CSF) autoantibody tests were performed using cell\u2010based indirect immunofluorescence assay for AIE diagnosis. Samples were provided by neurology clinics as part of a nationwide program. Test results were analyzed for samples received during the period from 2012 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We tested 1,247 samples from 1,034 patients with suspected AIE. Autoantibodies were present in 60 patients (5.8% of total). The distribution of patients with different autoantibodies by age and sex was as follows: NMDAR (70%), mostly in young females, LGI1 (15%) in middle\u2010aged males, GABA<jats:sub>B<\/jats:sub>R (12%) in elderly males, and Caspr2 (7%) in males. Long\u2010term follow\u2010up was conducted in 30 patients with repeated test requests, of which 17 remained positive, and 13 switched to negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report the most comprehensive clinical laboratory study of autoantibody testing in AIE in the Hungarian population. Our results show that the frequency of different autoantibody types in AIE corresponds to the data described in the literature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1454","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T03:30:07Z","timestamp":1571974207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Single\u2010center study of autoimmune encephalitis\u2010related autoantibody testing in Hungary"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2565-1144","authenticated-orcid":false,"given":"Zs\u00f3fia","family":"Hayden","sequence":"first","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"B\u00f6r\u00f6cz","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Csizmadia","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Balogh","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Kellermayer","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korn\u00e9lia","family":"Bod\u00f3","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Najbauer","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00edmea","family":"Berki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology Clinical Center University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13324"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.27"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708712"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.07.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1038"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00706"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2017.11.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0167-10.2010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14581\/jer.16010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12974"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3506-13.2013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00841"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.03.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.43"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.04.046"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32526-1"},{"issue":"40","key":"e_1_2_9_19_1","first-page":"666","article-title":"Autoantibody\u2010mediated encephalitis","volume":"115","author":"Wandinger K. 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