{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:43:49Z","timestamp":1792597429947,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to analyze the clinical, imaging, electrophysiological, and dermatopathological features of a patient with adult\u2010onset neuronal intranuclear inclusion disease (NIID) and to explore the diagnostic methods of adult\u2010onset NIID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We here report a 63\u2010year\u2010old male with recurrent acute encephalopathy syndrome and autonomic nervous system damage syndrome characterized by sexual dysfunction and urinary and fecal dysfunction. Cranial diffusion\u2010weighted magnetic resonance imaging (DWI) demonstrated symmetrically distributed strip\u2010shaped high\u2010intensity signal in bilateral fronto\u2010occipital\u2010parietal cortical\u2010medullary junction. Electrophysiological test revealed that the main site of injury was myelin sheath in both motor and sensory nerves. Skin biopsy revealed eosinophilic spherical inclusion bodies in the nucleus of sweat gland epithelial cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case suggests that adult NIID is a chronic neurodegenerative disease with high clinical heterogeneity. Subcortical strip\u2010shaped high\u2010intensity signal on DWI has high diagnostic significance. Eosinophilic intranuclear inclusion bodies detected by skin biopsy contribute to diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1477","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T07:15:06Z","timestamp":1574320506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adult\u2010onset neuronal intranuclear inclusion disease presenting with typical MRI changes"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-6652","authenticated-orcid":false,"given":"Xinsheng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaifeng Central Hospital Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daojun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University People's Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218790"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5544"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013544"},{"key":"e_1_2_6_5_1","first-page":"905","article-title":"Adult\u2010onset neuronal intranuclear inclusion disease: A case report and review of literature","volume":"51","author":"Chen W. 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