{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:10:28Z","timestamp":1790143828064,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accumulating evidence has pointed that T helper 17 cells and their cytokines are pathogenic in Guillain\u2013Barr\u00e9 syndrome (GBS). However, little is known concerning the IL\u201017 expression change trend during the whole course of disease, and whether drugs specially targeting Th17 cells or their cytokines have potential effects on experimental autoimmune neuritis (EAN) is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We explored the IL\u201017 and receptor\u2010related orphan receptor\u2010gamma\u2010t (ROR\u03b3t) expression change trends in EAN rats to identify the stage of effect of Th17 pathway in EAN, and further, we investigated the effect of ROR\u03b3t inhibitors by assessing clinical score, histological staining, and IL\u201017 and ROR\u03b3t expression change trends in serum and tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression level of IL\u201017 and ROR\u03b3t in serum and tissues increased with the progression of the disease in the EAN group and decreased after the disease reaching its peak. ROR\u03b3t\u2010IN\u20101 treatment strikingly reduced the neurological deficits by ameliorating inflammatory cell infiltration, deceased the serum IL\u201017 and ROR\u03b3t levels, and further downregulated the expression of IL\u201017 and ROR\u03b3t mRNA in spleen, lymphnodes, and sciatic nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Th17 cells and their cytokines are closely associated with the onset of GBS and the novel ROR\u03b3t inhibitors may be prospective strategies in treating GBS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1478","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T18:01:36Z","timestamp":1574186496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Th17 cells and their cytokines serve as potential therapeutic target in experimental autoimmune neuritis"],"prefix":"10.1002","volume":"9","author":[{"given":"Shuping","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Wuhan University, Renmin Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuhan University, Renmin Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheman","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuhan University, Renmin Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuhan University, Renmin Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurology Wuhan University, Renmin 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