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Twelve sciatica patients were enrolled to receive six or 18 acupoints of acupuncture treatment twice a week for 4\u00a0weeks. Regional homogeneity (ReHo) and seed\u2010based FC were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regional homogeneity analysis demonstrated a greater alteration in the right posterior cingulate cortex (PCC) during the pre\u2010acupuncture phase than during the postacupuncture phase. Compared to that of healthy controls, the PCC\u2010seeded FC (default mode network, DMN) of sciatica patients exhibited hyperconnectivity of PCC\u2010FC with the PCC\u2010bilateral insula, cerebellum, inferior parietal lobule, right medial prefrontal cortex, and dorsal anterior cingulate cortex during the pre\u2010acupuncture phase as well as hypoconnectivity of PCC\u2010FC with the right cerebellum, left precuneus, and left dorsal medial prefrontal cortex during the postacupuncture phase. Correlation analysis between PCC\u2010seeded FC and behavior measurements revealed a positive association with the duration of sciatica in the right inferior parietal lobule prior to acupuncture treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acupuncture in chronic sciatica patients is associated with normalized DMN activity and modulation of descending pain processing. The changes in the subclinical endophenotype of brain FC after acupuncture treatment may provide clues for understanding the mechanism of acupuncture\u2010mediated analgesia in chronic pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1494","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T18:25:47Z","timestamp":1578680747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in resting\u2010state functional connectivity in nonacute sciatica with acupuncture modulation: A preliminary study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-473X","authenticated-orcid":false,"given":"Ching\u2010Hsiung","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Lotung Poh\u2010Ai Hospital Ilan Taiwan"},{"name":"Institute of Traditional Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Integrated Brain Research Unit Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yeh","sequence":"additional","affiliation":[{"name":"Integrated Brain Research Unit Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Radiology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Ying","family":"Kung","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Center for Traditional Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Pin","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Neurology Lotung Poh\u2010Ai Hospital Ilan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Ju","family":"Yang","sequence":"additional","affiliation":[{"name":"Integrated Brain Research Unit Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Yi","family":"Hong","sequence":"additional","affiliation":[{"name":"Integrated Brain Research Unit Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chou\u2010Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Integrated Brain Research Unit Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Traditional Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Peng","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Traditional Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Chuen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Integrated Brain Research Unit Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Brain Research Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Pey","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Center for Traditional Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.019"},{"key":"e_1_2_9_3_1","first-page":"95","volume-title":"Occupational low back pain: Assessment, treatment and retention","author":"Andersson G. 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