{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:02:52Z","timestamp":1771707772884,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Delayed cerebral ischemia (DCI) greatly contributes to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. Expression of lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 (LOX\u20101) was substantially raised in the basilar arterial wall of SAH rabbits. We attempted to ascertain the relationship between serum soluble LOX\u20101 (sLOX\u20101) levels and the occurrence of DCI after aSAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We enrolled 125 aSAH patients and 125 healthy controls. Serum sLOX\u20101 levels were quantified using commercial enzyme\u2010linked immunosorbent assay kit. The relationship between sLOX\u20101 levels and DCI was analyzed utilizing the multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum sLOX\u20101 levels were significantly higher in stroke patients than in controls (median: 1,450.2 vs. 445.7\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Serum sLOX\u20101 levels were highly correlated with World Federation of Neurological Surgeons (WFNS) scores, Hunt\u2010Hess scores, and modified Fisher scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.574, .625, and .569, respectively). Forty\u2010two patients (33.6%) experienced DCI. Serum sLOX\u20101\u00a0&gt;\u00a01,450.2\u00a0pg\/ml, WFNS scores and modified Fisher scores were the independent predictors of DCI. Under receiver operating characteristic curve, serum sLOX\u20101 levels exhibited a significant discriminatory capability (area under curve 0.825, 95% confidence interval 0.747\u20130.887). The predictive power of serum sLOX\u20101 levels was similar to those of WFNS scores and modified Fisher grade (both <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). Moreover, serum sLOX\u20101 levels significantly improved their predictive capability (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum soluble LOX\u20101, in positive association with hemorrhagic severity, appears to have the potential to become a promising predictor of DCI after aSAH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1517","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T17:43:34Z","timestamp":1579023814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum soluble lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 as a biomarker of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage"],"prefix":"10.1002","volume":"10","author":[{"given":"Qun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Central Hospital of Wenzhou City Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua\u2010Jun","family":"Ba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Central Hospital of Wenzhou City Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Xia","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Central Hospital of Wenzhou City Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Central Hospital of Wenzhou City Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Central Hospital of Wenzhou City Wenzhou 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