{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:01:51Z","timestamp":1787605311492,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Memory & Aging at HealthPartners Institute"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Brain and Behavior"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intranasal deferoxamine (IN DFO) has been shown to decrease memory loss and have beneficial impacts across several models of neurologic disease and injury, including rodent models of Alzheimer's and Parkinson's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In order to assess the mechanism of DFO, determine its ability to improve memory from baseline in the absence of a diseased state, and assess targeting ability of intranasal delivery, we treated healthy mice with IN DFO (2.4\u00a0mg) or intraperitoneal (IP) DFO and compared behavioral and biochemical changes with saline\u2010treated controls. Mice were treated 5\u00a0days\/week for 4\u00a0weeks and subjected to behavioral tests 30\u00a0min after dosing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that IN DFO, but not IP DFO, significantly enhanced working memory in the radial arm water maze, suggesting that IN administration is more efficacious as a targeted delivery route to the brain. Moreover, the ability of DFO to improve memory from baseline in healthy mice suggests a non\u2010disease\u2010specific mechanism of memory improvement. IN DFO treatment was accompanied by decreased GSK\u20103\u03b2 activity and increased HIF\u20101\u03b1 activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These pathways are suspected in DFO's ability to improve memory and perhaps represent a component of the common mechanism through which DFO enacts beneficial change in models of neurologic disease and injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/brb3.1536","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T02:37:10Z","timestamp":1579574230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non\u2010disease\u2010specific pathway of functional neurologic improvement"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-9065","authenticated-orcid":false,"given":"Jared M.","family":"Fine","sequence":"first","affiliation":[{"name":"Neuroscience Research at HealthPartners Institute Saint Paul MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Kosyakovsky","sequence":"additional","affiliation":[{"name":"Neuroscience Research at HealthPartners Institute Saint Paul MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Baillargeon","sequence":"additional","affiliation":[{"name":"Neuroscience Research at HealthPartners Institute Saint Paul MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian V.","family":"Tokarev","sequence":"additional","affiliation":[{"name":"Neuroscience Research at HealthPartners Institute Saint Paul MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob 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