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In this case report, we compared the topographical relationship of cerebral glucose metabolism and antigen distribution in the patients with anti\u2010NMDAR and anti\u2010AMPAR encephalitis. Literature review summarized the common features of brain metabolism of autoimmune encephalitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cerebral glucose metabolism was evaluated by FDG\u2010PET\/CT during acute\u2010to\u2010subacute stage of autoimmune encephalitis and after treatment. The stereo and quantitative analysis of cerebral metabolism used standardized <jats:italic>z<\/jats:italic>\u2010score and visualized on three\u2010dimensional stereotactic surface projection. To map NMDAR and AMPAR in human brain, we adopted genetic atlases from the Allen Institute and protein atlases from Zilles's receptor densities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The three\u2010dimensional stereotactic surface projection displayed frontal\u2010dominant hypometabolism in a 66\u2010year\u2010old female patient with anti\u2010AMPAR encephalitis and occipital\u2010dominant hypometabolism in a 29\u2010year\u2010old female patient with anti\u2010NMDAR encephalitis. Receptor density maps revealed opposite frontal\u2013occipital gradients of AMPAR and NMDAR, which reflect reduced metabolism in the correspondent encephalitis. FDG\u2010PET hypometabolic areas possibly represent receptor hypofunction with spatial correspondence to receptor distributions of the autoimmune encephalitis. The reversibility of hypometabolism was in line with patients' cognitive improvement. The literature review summarized six features of metabolic anomalies of autoimmune encephalitis: (a) temporal hypermetabolism, (b) frontal hypermetabolism and (c) occipital hypometabolism in anti\u2010NMDAR encephalitis, (d) hypometabolism in association cortices, (e) sparing of unimodal primary motor cortex, and (e) reversibility in recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The distinct cerebral hypometabolic patterns of autoimmune encephalitis were representative for receptor hypofunction and topographical distribution of antigenic receptors. The reversibility of hypometabolism marked the clinical recovery of autoimmune encephalitis and made FDG\u2010PET of brain a valuable diagnostic tool.<\/jats:p><\/jats:sec>","DOI":"10.1002\/brb3.1540","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T12:26:59Z","timestamp":1580128019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Different FDG\u2010PET metabolic patterns of anti\u2010AMPAR and anti\u2010NMDAR encephalitis: Case report and literature review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-3134","authenticated-orcid":false,"given":"Yi\u2010Chia","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology Chang Gung Memorial Hospital Keelung Taiwan"},{"name":"Institute of Neuroscience National Yang Ming University Taipei Taiwan"},{"name":"Community Medicine Research Center Chang Gung Memorial 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